Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3396052..3396679 Replicon chromosome
Accession NZ_CP062254
Organism Pectobacterium parmentieri strain QK-5

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag IG623_RS15595 Protein ID WP_005976087.1
Coordinates 3396476..3396679 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag IG623_RS15590 Protein ID WP_005976089.1
Coordinates 3396052..3396420 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG623_RS15575 3391523..3394651 + 3129 WP_015730969.1 multidrug efflux RND transporter permease subunit -
IG623_RS15580 3394884..3395132 + 249 WP_015730970.1 type B 50S ribosomal protein L31 -
IG623_RS15585 3395150..3395293 + 144 WP_005976091.1 type B 50S ribosomal protein L36 -
IG623_RS15590 3396052..3396420 + 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
IG623_RS15595 3396476..3396679 + 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
IG623_RS15605 3397407..3397727 + 321 WP_005976085.1 MGMT family protein -
IG623_RS15610 3397747..3398331 - 585 WP_015730971.1 YbaY family lipoprotein -
IG623_RS15615 3398542..3399405 + 864 WP_014700820.1 acyl-CoA thioesterase II -
IG623_RS15620 3399523..3400809 - 1287 WP_014700821.1 ammonium transporter AmtB -
IG623_RS15625 3400849..3401187 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T174178 WP_005976087.1 NZ_CP062254:3396476-3396679 [Pectobacterium parmentieri]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T174178 NZ_CP080566:c1614880-1614635 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT174178 WP_005976089.1 NZ_CP062254:3396052-3396420 [Pectobacterium parmentieri]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT174178 NZ_CP080566:1614301-1614666 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References