Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 875809..876469 Replicon chromosome
Accession NZ_CP062254
Organism Pectobacterium parmentieri strain QK-5

Toxin (Protein)


Gene name cptA Uniprot ID A0A8B3EZX7
Locus tag IG623_RS04190 Protein ID WP_012822581.1
Coordinates 876056..876469 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3I0G9
Locus tag IG623_RS04185 Protein ID WP_012822580.1
Coordinates 875809..876075 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG623_RS04165 871801..872805 - 1005 WP_103807861.1 substrate-binding domain-containing protein -
IG623_RS04170 872859..873467 - 609 WP_014698756.1 HD domain-containing protein -
IG623_RS04175 873878..874525 + 648 WP_012822578.1 hemolysin III family protein -
IG623_RS04180 874580..875581 - 1002 WP_012822579.1 tRNA-modifying protein YgfZ -
IG623_RS04185 875809..876075 + 267 WP_012822580.1 FAD assembly factor SdhE Antitoxin
IG623_RS04190 876056..876469 + 414 WP_012822581.1 protein YgfX Toxin
IG623_RS04195 876695..877630 + 936 WP_012822582.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
IG623_RS04200 877718..878041 - 324 WP_012822583.1 hypothetical protein -
IG623_RS04205 878070..878588 - 519 WP_012822584.1 flavodoxin FldB -
IG623_RS04210 878916..879932 + 1017 WP_012822585.1 methionine ABC transporter ATP-binding protein -
IG623_RS04215 879925..880593 + 669 WP_012822586.1 ABC transporter permease -
IG623_RS04220 880611..881429 + 819 WP_033071942.1 MetQ/NlpA family ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16259.20 Da        Isoelectric Point: 10.7923

>T174176 WP_012822581.1 NZ_CP062254:876056-876469 [Pectobacterium parmentieri]
VAQWQCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGCITLLSETTLNWRQQ
EWRIVKRPWLLKNGVLLALQSANGKDKQQLWLASDSMGDDEWRHLRQLLLQQKHWAR

Download         Length: 414 bp

>T174176 NZ_CP080566:c1108424-1107960 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCACGT
AGACACGGCTTTATCTCAGCTGTTCCATTACGTGAAATTGTAGAAGCTTATAATTATGGCGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCGATAGAACAATATAAAAAGATATACGGTATTGGTACCC
ACTACGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCATATTGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10519.99 Da        Isoelectric Point: 5.1392

>AT174176 WP_012822580.1 NZ_CP062254:875809-876075 [Pectobacterium parmentieri]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDIDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT174176 NZ_CP080566:c1108760-1108437 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAGA
TTGCCAACGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3EZX7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3I0G9

References