Detailed information of TA system TA174168

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 5368257..5368762
• Replicon: chromosome
• Accession: NZ_CP062253
• Organism: Pseudomonas gozinkensis strain IzPS32d

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q3K782
• Locus tag: IHQ43_RS23830
• Protein ID: WP_011335833.1
• Coordinates: 5368508..5368762 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: IHQ43_RS23825
• Protein ID: WP_192562325.1
• Coordinates: 5368257..5368511 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IHQ43_RS23800	5363565..5363933	-	369	WP_095191588.1	PH domain-containing protein	-
IHQ43_RS23805	5363972..5364718	-	747	WP_192562321.1	hypothetical protein	-
IHQ43_RS23810	5364839..5365213	+	375	WP_192562322.1	hypothetical protein	-
IHQ43_RS23815	5365324..5366067	+	744	WP_192562323.1	hypothetical protein	-
IHQ43_RS23820	5366138..5368057	+	1920	WP_192562324.1	alkaline phosphatase family protein	-
IHQ43_RS23825	5368257..5368511	+	255	WP_192562325.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
IHQ43_RS23830	5368508..5368762	+	255	WP_011335833.1	Txe/YoeB family addiction module toxin	Toxin
IHQ43_RS23835	5368771..5369943	-	1173	WP_192562326.1	aspartate aminotransferase family protein	-
IHQ43_RS23840	5370046..5370951	+	906	WP_192562327.1	LysR family transcriptional regulator	-
IHQ43_RS23845	5370997..5371401	+	405	WP_192562328.1	GNAT family N-acetyltransferase	-
IHQ43_RS23850	5371577..5373058	+	1482	WP_192562329.1	MBOAT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9950.59 Da
• Isoelectric Point: 9.6300

>T174168 WP_011335833.1 NZ_CP062253:5368508-5368762 [Pseudomonas gozinkensis]
MKIQFTPTGWEDYLWFQQNDKAGLKRINLLIKAIQRQPFEGLGKPEPLKHNMSGFWSRRITAEHRLVYAIVDGEICVITC
RFHY

Nucleotide

• Length: 255 bp

>T174168 NZ_CP080564:c2082114-2081752 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9465.92 Da
• Isoelectric Point: 5.1314

>AT174168 WP_192562325.1 NZ_CP062253:5368257-5368511 [Pseudomonas gozinkensis]
MDTINYTTARAHLAETMDRVNEDCAPLLVTRQKGEPVVMMSLAEYNALEETAYLLRSPANAERLIKSIGEMRAGKVKVRQ
LIEE

Nucleotide

• Length: 255 bp

>AT174168 NZ_CP080564:c2082281-2082111 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Toxin

• AlphaFold DB: Q3K782