Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/Acetyltransf_9(toxin)
Location 2913532..2915242 Replicon chromosome
Accession NZ_CP062253
Organism Pseudomonas gozinkensis strain IzPS32d

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IHQ43_RS12890 Protein ID WP_192564659.1
Coordinates 2913532..2914599 (-) Length 356 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IHQ43_RS12895 Protein ID WP_192564660.1
Coordinates 2914685..2915242 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHQ43_RS12860 2909312..2909920 - 609 WP_192564654.1 3-isopropylmalate dehydratase small subunit -
IHQ43_RS12865 2909924..2911345 - 1422 WP_192564655.1 3-isopropylmalate dehydratase large subunit -
IHQ43_RS12870 2911481..2911966 - 486 WP_192564656.1 MaoC family dehydratase -
IHQ43_RS12875 2911963..2912307 - 345 Protein_2528 3-methyl-2-oxobutanoate hydroxymethyltransferase -
IHQ43_RS12880 2912325..2912942 - 618 WP_192564657.1 LysE family translocator -
IHQ43_RS12885 2913065..2913517 + 453 WP_192564658.1 Lrp/AsnC family transcriptional regulator -
IHQ43_RS12890 2913532..2914599 - 1068 WP_192564659.1 GNAT family N-acetyltransferase Toxin
IHQ43_RS12895 2914685..2915242 - 558 WP_192564660.1 helix-turn-helix domain-containing protein Antitoxin
IHQ43_RS12900 2915321..2915725 - 405 WP_192564661.1 RidA family protein -
IHQ43_RS12905 2915859..2916806 + 948 WP_192564662.1 LysR family transcriptional regulator -
IHQ43_RS12910 2916874..2918034 + 1161 WP_192564663.1 radical SAM protein -
IHQ43_RS12915 2918016..2918903 - 888 WP_192564664.1 LysR family transcriptional regulator -
IHQ43_RS12920 2919041..2920093 + 1053 WP_192564665.1 agmatine deiminase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(9-165)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 356 a.a.        Molecular weight: 38963.98 Da        Isoelectric Point: 4.8049

>T174166 WP_192564659.1 NZ_CP062253:c2914599-2913532 [Pseudomonas gozinkensis]
MNLEKIKGRLDFLREAERLKDVLRSAHTSSGRSESTAEHSWRLCLMAIVFADDLAGLDVLKVLKMCVIHDLGEAINGDIP
AVDQAGLPDKGEQERNDLLLLIRSLDDALRDEILALWDDYENASSPEAKAVKALDKLETLLQHTQGKNPPDFDYGFNLAY
GKQYTNADPLFETLRTLIDRDTRERMNTNITIRNERPEDIDAIARITEAAFQHEEHSSHTEHFIVNALRRAGQLSVSLVA
VENDTVVGHVAISPVTISSGAQGWYGLGPISVCPTRQQQGIGSALMKASLAQLQRIGGVGCVVLGDPGYYGRFGFKTHAG
LELPGIPAEYFQALAFEGELPVGVVSYHEAFDATA

Download         Length: 1068 bp

>T174166 NZ_CP080564:c1873463-1873311 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20528.51 Da        Isoelectric Point: 7.8760

>AT174166 WP_192564660.1 NZ_CP062253:c2915242-2914685 [Pseudomonas gozinkensis]
MSDTLLKPSLPGIALRRWRVLHRVKQSHAAELFKVTQSTISRWESGVQAMDPDAHLQLERLLAARLDSAADQALARLVTD
SARPVHLVCDLTHRLLACSPTRAAQFSSPLSDLLGQSLWRFATAQIQHKESLLDDTGWREVPAPPALEFVTGHNDSTLVP
IRESLCRWTRIALSDGTAARLVETL

Download         Length: 558 bp

>AT174166 NZ_CP080564:c1874087-1873488 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGGGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References