Detailed information of TA system TA174152

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 4774068..4774744
• Replicon: chromosome
• Accession: NZ_CP062251
• Organism: Pseudomonas sp. IzPS59

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: IF189_RS21390
• Protein ID: WP_065259289.1
• Coordinates: 4774068..4774421 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: IF189_RS21395
• Protein ID: WP_065259290.1
• Coordinates: 4774424..4774744 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF189_RS21365	4769357..4770553	-	1197	WP_192552213.1	hypothetical protein	-
IF189_RS21370	4770680..4771828	-	1149	WP_192552214.1	hypothetical protein	-
IF189_RS21375	4771919..4772734	-	816	WP_192552215.1	sulfite exporter TauE/SafE family protein	-
IF189_RS21380	4772847..4773614	+	768	WP_192552216.1	helix-turn-helix transcriptional regulator	-
IF189_RS21385	4773708..4774025	+	318	WP_192552217.1	XRE family transcriptional regulator	-
IF189_RS21390	4774068..4774421	+	354	WP_065259289.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IF189_RS21395	4774424..4774744	+	321	WP_065259290.1	helix-turn-helix domain-containing protein	Antitoxin
IF189_RS21400	4774757..4775809	-	1053	WP_192552218.1	MBL fold metallo-hydrolase	-
IF189_RS21405	4776025..4776633	+	609	WP_192552219.1	TetR/AcrR family transcriptional regulator	-
IF189_RS21410	4776779..4777831	+	1053	WP_192553598.1	diguanylate cyclase	-
IF189_RS21415	4778016..4779335	+	1320	WP_192552220.1	PAS domain-containing methyl-accepting chemotaxis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4766377..4774744	8367

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (15-107)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 12986.93 Da
• Isoelectric Point: 9.7422

>T174152 WP_065259289.1 NZ_CP062251:4774068-4774421 [Pseudomonas sp. IzPS59]
MSTRKPLLWVSSSKKDLKQMPTDVQDVFGYALDLAQSGLRHPDAKPLKGFGGAGVLELIEDFDTNTYRAVYTVRFGNAIY
VLHCFQKKSTAGIKTAQCDIDLIRKRLQAAQDHAKGT

Nucleotide

• Length: 354 bp

>T174152 NZ_CP080560:c2097367-2097215 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11690.56 Da
• Isoelectric Point: 9.0798

>AT174152 WP_065259290.1 NZ_CP062251:4774424-4774744 [Pseudomonas sp. IzPS59]
MNEIEEGSGNVYQDLGLPNASEMQVKSQLAAKIGEIIKARHLTQSQASEILGLSQPKLSEMLRGKFRGISEAKMMECLSH
LGRDVQIVVKPAPRSRKEGRIEVVFA

Nucleotide

• Length: 321 bp

>AT174152 NZ_CP080560:c2097991-2097392 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA