Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 485021..485610 Replicon chromosome
Accession NZ_CP062251
Organism Pseudomonas sp. IzPS59

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag IF189_RS02155 Protein ID WP_102620197.1
Coordinates 485021..485326 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q3KJ92
Locus tag IF189_RS02160 Protein ID WP_011332089.1
Coordinates 485323..485610 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF189_RS02135 481051..482118 + 1068 WP_007952372.1 uroporphyrinogen decarboxylase -
IF189_RS02140 482175..483449 - 1275 WP_134825221.1 MFS transporter -
IF189_RS02145 483568..484464 + 897 WP_039766450.1 LysR family transcriptional regulator -
IF189_RS02150 484465..484902 - 438 WP_085711066.1 excinuclease -
IF189_RS02155 485021..485326 + 306 WP_102620197.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IF189_RS02160 485323..485610 + 288 WP_011332089.1 putative addiction module antidote protein Antitoxin
IF189_RS02165 485658..486098 - 441 WP_119429522.1 excinuclease -
IF189_RS02170 486119..487354 - 1236 WP_134825223.1 beta-ketoacyl-ACP synthase -
IF189_RS02175 487354..488082 - 729 WP_085711069.1 3-oxoacyl-ACP reductase FabG -
IF189_RS02180 488075..488539 - 465 WP_085711070.1 hotdog family protein -
IF189_RS02185 488536..489732 - 1197 WP_192552749.1 beta-ketoacyl-[acyl-carrier-protein] synthase family protein -
IF189_RS02190 489729..490211 - 483 WP_192552750.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-91)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11469.08 Da        Isoelectric Point: 9.6535

>T174147 WP_102620197.1 NZ_CP062251:485021-485326 [Pseudomonas sp. IzPS59]
MTEILRSSTFSSWLVKLADSRARMRIQVRIDRMADGNFGDVKAIGEGISEARIDYGPGYRVYFMQQGRQLVILLCGGDKS
SQSRDIKQARLIAESWQEQNP

Download         Length: 306 bp

>T174147 NZ_CP080556:c2313799-2313695 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10446.86 Da        Isoelectric Point: 4.6412

>AT174147 WP_011332089.1 NZ_CP062251:485323-485610 [Pseudomonas sp. IzPS59]
MTEQFTRWDSAEYLKTEEDMANYLDACMEEAGDDPAFIAKALGTIARARGMTQVARDAGLSRESLYRALSGEVNPEFGTI
LKVMKALGLKLHAST

Download         Length: 288 bp

>AT174147 NZ_CP080556:2313582-2313637 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A345RJ97

References