Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4439463..4440058 Replicon chromosome
Accession NZ_CP062249
Organism Escherichia coli strain AML002_ev01

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag IHN46_RS21405 Protein ID WP_000239577.1
Coordinates 4439708..4440058 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag IHN46_RS21400 Protein ID WP_001223208.1
Coordinates 4439463..4439714 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHN46_RS21390 4435128..4438907 + 3780 WP_000060911.1 autotransporter assembly complex protein TamB -
IHN46_RS21395 4438910..4439251 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
IHN46_RS21400 4439463..4439714 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
IHN46_RS21405 4439708..4440058 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
IHN46_RS21410 4440138..4440668 - 531 WP_000055075.1 inorganic diphosphatase -
IHN46_RS21415 4440978..4441934 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
IHN46_RS21420 4442074..4443576 + 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
IHN46_RS21425 4443590..4444612 + 1023 WP_001313531.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T174097 WP_000239577.1 NZ_CP062249:4439708-4440058 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T174097 NZ_CP080548:1990138-1990233 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT174097 WP_001223208.1 NZ_CP062249:4439463-4439714 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT174097 NZ_CP080548:c1990318-1990261 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References