Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | rnlAB/RnlA-RnlB |
Location | 2760476..2761913 | Replicon | chromosome |
Accession | NZ_CP062249 | ||
Organism | Escherichia coli strain AML002_ev01 |
Toxin (Protein)
Gene name | rnlA | Uniprot ID | P52129 |
Locus tag | IHN46_RS13440 | Protein ID | WP_000155570.1 |
Coordinates | 2760476..2761549 (+) | Length | 358 a.a. |
Antitoxin (Protein)
Gene name | rnlB | Uniprot ID | P52130 |
Locus tag | IHN46_RS13445 | Protein ID | WP_000461704.1 |
Coordinates | 2761542..2761913 (+) | Length | 124 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IHN46_RS13425 | 2755909..2758098 | - | 2190 | WP_000136402.1 | DEAD/DEAH box helicase | - |
IHN46_RS13430 | 2758095..2759711 | - | 1617 | WP_000445380.1 | anti-bacteriophage protein AbpA | - |
IHN46_RS13435 | 2760071..2760334 | - | 264 | WP_000502050.1 | DUF1524 domain-containing protein | - |
IHN46_RS13440 | 2760476..2761549 | + | 1074 | WP_000155570.1 | type II toxin-antitoxin system toxin mRNA endoribonuclease RnlA | Toxin |
IHN46_RS13445 | 2761542..2761913 | + | 372 | WP_000461704.1 | type II toxin-antitoxin system antitoxin RnlB | Antitoxin |
IHN46_RS13450 | 2762268..2763131 | + | 864 | WP_000787597.1 | GTPase family protein | - |
IHN46_RS13455 | 2763223..2764044 | + | 822 | WP_000197391.1 | DUF945 domain-containing protein | - |
IHN46_RS13460 | 2764261..2764962 | + | 702 | WP_000189409.1 | WYL domain-containing protein | - |
IHN46_RS13465 | 2765003..2765239 | + | 237 | WP_001144029.1 | hypothetical protein | - |
IHN46_RS13470 | 2765239..2765682 | + | 444 | WP_000824222.1 | hypothetical protein | - |
IHN46_RS13475 | 2765706..2766173 | + | 468 | WP_000702495.1 | hypothetical protein | - |
IHN46_RS13480 | 2766398..2766712 | - | 315 | WP_000065803.1 | arsenate reductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 358 a.a. Molecular weight: 40061.13 Da Isoelectric Point: 6.8293
>T174087 WP_000155570.1 NZ_CP062249:2760476-2761549 [Escherichia coli]
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
Download Length: 1074 bp
>T174087 NZ_CP080536:c928188-927934 [Acidithiobacillus ferriphilus]
GTGAGGCTGATCTTCTCTGACGATGCATGGGAAGACTACCTATATTGGCAGAAGCAAGACAAGCGCGTGGTCGAGCGAAT
CAATAAGCTGATACGTGAGACACAGCGTGAACCCTTCGCGGGAGTTGGCAAACCCGAAGCACTGAAGCATGCTCTTTCAG
GATTTTGGTCACGCCGTATTACAGATGAGCATCGCATGGTGTATCGAATAGAAGGTGATGCATTGATGATTGCTCAGTTG
CGTTTCCACTACTGA
GTGAGGCTGATCTTCTCTGACGATGCATGGGAAGACTACCTATATTGGCAGAAGCAAGACAAGCGCGTGGTCGAGCGAAT
CAATAAGCTGATACGTGAGACACAGCGTGAACCCTTCGCGGGAGTTGGCAAACCCGAAGCACTGAAGCATGCTCTTTCAG
GATTTTGGTCACGCCGTATTACAGATGAGCATCGCATGGTGTATCGAATAGAAGGTGATGCATTGATGATTGCTCAGTTG
CGTTTCCACTACTGA
Antitoxin
Download Length: 124 a.a. Molecular weight: 13664.69 Da Isoelectric Point: 4.2391
>AT174087 WP_000461704.1 NZ_CP062249:2761542-2761913 [Escherichia coli]
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
Download Length: 372 bp
>AT174087 NZ_CP080536:c928436-928185 [Acidithiobacillus ferriphilus]
ATGGATGCGATTACCTATACCACCGTTCGTGCAAATCTCGCCAGCGCCATGGACCGCGTTTGCGACGACCACGAACCCTT
GATCATTACCCGCAATGGCGAACAGTCCGTCGTGATGCTCTCGCTCGAAGACTACAAGGCGCTGGAGGAAACCGCCTACC
TCTTGCGTACCCCCGCCAACGCCAAGCGCCTTCTCGCTGCCGTCGCACAACTGAACGCCGGTAAAGGCGTTGAGCGGAAG
CTGGCGAAGTGA
ATGGATGCGATTACCTATACCACCGTTCGTGCAAATCTCGCCAGCGCCATGGACCGCGTTTGCGACGACCACGAACCCTT
GATCATTACCCGCAATGGCGAACAGTCCGTCGTGATGCTCTCGCTCGAAGACTACAAGGCGCTGGAGGAAACCGCCTACC
TCTTGCGTACCCCCGCCAACGCCAAGCGCCTTCTCGCTGCCGTCGCACAACTGAACGCCGGTAAAGGCGTTGAGCGGAAG
CTGGCGAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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