Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
Location | 1504742..1505380 | Replicon | chromosome |
Accession | NZ_CP062249 | ||
Organism | Escherichia coli strain AML002_ev01 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | S1F9G9 |
Locus tag | IHN46_RS07365 | Protein ID | WP_000813794.1 |
Coordinates | 1504742..1504918 (+) | Length | 59 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | - |
Locus tag | IHN46_RS07370 | Protein ID | WP_001270286.1 |
Coordinates | 1504964..1505380 (+) | Length | 139 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IHN46_RS07345 | 1500361..1501575 | - | 1215 | WP_001326689.1 | BenE family transporter YdcO | - |
IHN46_RS07350 | 1501628..1502164 | + | 537 | WP_000429155.1 | DNA-binding transcriptional regulator SutR | - |
IHN46_RS07355 | 1502237..1504198 | + | 1962 | WP_001303492.1 | 23S rRNA 5-hydroxycytidine C2501 synthase | - |
IHN46_RS07360 | 1504290..1504520 | - | 231 | WP_000494244.1 | YncJ family protein | - |
IHN46_RS07365 | 1504742..1504918 | + | 177 | WP_000813794.1 | type II toxin-antitoxin system mRNA interferase toxin HicA | Toxin |
IHN46_RS07370 | 1504964..1505380 | + | 417 | WP_001270286.1 | type II toxin-antitoxin system antitoxin HicB | Antitoxin |
IHN46_RS07375 | 1505459..1506865 | + | 1407 | WP_000760626.1 | PLP-dependent aminotransferase family protein | - |
IHN46_RS07380 | 1507110..1508255 | + | 1146 | WP_000047424.1 | ABC transporter substrate-binding protein | - |
IHN46_RS07385 | 1508273..1509286 | + | 1014 | WP_000220396.1 | ABC transporter ATP-binding protein | - |
IHN46_RS07390 | 1509287..1510228 | + | 942 | WP_001251304.1 | ABC transporter permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6749.83 Da Isoelectric Point: 11.2298
>T174074 WP_000813794.1 NZ_CP062249:1504742-1504918 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS
Download Length: 177 bp
>T174074 NZ_CP080530:c78960-78091 [Mesorhizobium sp. AR02]
ATGGCTAAGGAGATCAAGAACATCGGCGCCTCGGTGCGCGCACGCCTGCTGCAACTCGCCAAGGCAAGTGGCCAGAGCTT
CGACCTGGTTCTGACACGCTTCGCGCTGGAGCGGCTGCTCTTCCGGCTCAGCCAGTCACGGCATGCCGACCGCTTCGTGC
TGAAGGGCGCGATGCTGATGATGAGCTGGTTCGATGATCCGCACCGCGGCACCCGCGACCTTGACCTGCTGGGTTTTGGC
GATCCGAGCGCGGAGCCGATGCTGGCGACGTTTCGGGAGATCCTGGCGCAGGACGCCGGCGATGGCGTCGAGTTCGACGC
TGACGCACTTCGCGTCGACCGCATTCGCGAGGAGCTGGAATATGGCGGGCTGCGACGGAGGACGACGGCCTCGATCAGCG
GCGCCCGGATCAGCCTGACGATCGACATCGGCTTTGGCGATGCGCTGGAGCCTGGAACTGAGGATCTGGACTATCCGTCC
ATGCTGGACTTTCCCATGCCCCGGCTGCGGGGCTATGCGCGGGAAACCGTCATTGCCGAGAAATTCCAGGCGATGGTGGC
GCTGGGGCGGGCGAATAGCCGGATGAAGGACTTCTACGACATCTGGATTCTCAGTCGCTCGTTCACCTTCGACGACGACA
GGCTGCCACGAGCGATTTCCGCCACCTTCGCGCGACGCGGAACAGCAATACCTCAAGACCTGCCCGATGCGCTGACACCA
GCCTTTGCCGAGGATGCGCAAAAGCAGCGACAGTGGCGTGCGTTTGTCGGAGATGTCGCCCACGATCCGGGTGATCTGGG
AAACGTCACTAGAGATATAGCGGCATTCCTCATGCGCCACGCGGTCTCAGCAGCGAGCTTGGGTAAATGA
ATGGCTAAGGAGATCAAGAACATCGGCGCCTCGGTGCGCGCACGCCTGCTGCAACTCGCCAAGGCAAGTGGCCAGAGCTT
CGACCTGGTTCTGACACGCTTCGCGCTGGAGCGGCTGCTCTTCCGGCTCAGCCAGTCACGGCATGCCGACCGCTTCGTGC
TGAAGGGCGCGATGCTGATGATGAGCTGGTTCGATGATCCGCACCGCGGCACCCGCGACCTTGACCTGCTGGGTTTTGGC
GATCCGAGCGCGGAGCCGATGCTGGCGACGTTTCGGGAGATCCTGGCGCAGGACGCCGGCGATGGCGTCGAGTTCGACGC
TGACGCACTTCGCGTCGACCGCATTCGCGAGGAGCTGGAATATGGCGGGCTGCGACGGAGGACGACGGCCTCGATCAGCG
GCGCCCGGATCAGCCTGACGATCGACATCGGCTTTGGCGATGCGCTGGAGCCTGGAACTGAGGATCTGGACTATCCGTCC
ATGCTGGACTTTCCCATGCCCCGGCTGCGGGGCTATGCGCGGGAAACCGTCATTGCCGAGAAATTCCAGGCGATGGTGGC
GCTGGGGCGGGCGAATAGCCGGATGAAGGACTTCTACGACATCTGGATTCTCAGTCGCTCGTTCACCTTCGACGACGACA
GGCTGCCACGAGCGATTTCCGCCACCTTCGCGCGACGCGGAACAGCAATACCTCAAGACCTGCCCGATGCGCTGACACCA
GCCTTTGCCGAGGATGCGCAAAAGCAGCGACAGTGGCGTGCGTTTGTCGGAGATGTCGCCCACGATCCGGGTGATCTGGG
AAACGTCACTAGAGATATAGCGGCATTCCTCATGCGCCACGCGGTCTCAGCAGCGAGCTTGGGTAAATGA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15246.63 Da Isoelectric Point: 4.7386
>AT174074 WP_001270286.1 NZ_CP062249:1504964-1505380 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV
Download Length: 417 bp
>AT174074 NZ_CP080530:c79558-78953 [Mesorhizobium sp. AR02]
ATGTCCCAACGCCAGATTGCCCATACCGTGCTGACCGCGCGCGGAATTTCGCGTCTGGCAGAGCTGCGCGAGGCGGGCGT
AACAGCCGCCACCATGAGTCGCATGGAACGCGACGGCGAGGTGCTTCGGCTCGCGCGAGGACTTTATCAACTTTCCGATG
CGCCCCTCGACGTTCACCACAGTCTCGCAGAGGCCGCCAAACGGGTTCCCAAAGGCGTGGTTTGCCTCGTTTCGGCCCTG
GCTTTCCATGGTCTGACTGATCAGCTCCCGAGGCAGGTTTGGCTCGCCGTGGGCCAGAAGGACTGGCCTCCCAAACCCGA
CGGCACACCCATTCGCATCGTGCGTTTTACCGAACGTCTGCTCAACGACAGCGTCGAAACTCATGTCATCGAAGGCGTGC
CCATAAAGGTTTTTGGCGTCATCAAAACTGTCGCGGACTGCTTCCGATATCGCAACAAGATCGGCCTTTCGGTGGCGATC
GAGGGTCTCCAGGAAGCACTCCGCCAGCGCAAGGCCACGCCCGGCGAAATTGCCAGGCAGGCCGAGCATGGAGGTGTCTC
TACGGTGATCCGGCCGTATCTTGAGGCACTCACCGCCAATGGCTAA
ATGTCCCAACGCCAGATTGCCCATACCGTGCTGACCGCGCGCGGAATTTCGCGTCTGGCAGAGCTGCGCGAGGCGGGCGT
AACAGCCGCCACCATGAGTCGCATGGAACGCGACGGCGAGGTGCTTCGGCTCGCGCGAGGACTTTATCAACTTTCCGATG
CGCCCCTCGACGTTCACCACAGTCTCGCAGAGGCCGCCAAACGGGTTCCCAAAGGCGTGGTTTGCCTCGTTTCGGCCCTG
GCTTTCCATGGTCTGACTGATCAGCTCCCGAGGCAGGTTTGGCTCGCCGTGGGCCAGAAGGACTGGCCTCCCAAACCCGA
CGGCACACCCATTCGCATCGTGCGTTTTACCGAACGTCTGCTCAACGACAGCGTCGAAACTCATGTCATCGAAGGCGTGC
CCATAAAGGTTTTTGGCGTCATCAAAACTGTCGCGGACTGCTTCCGATATCGCAACAAGATCGGCCTTTCGGTGGCGATC
GAGGGTCTCCAGGAAGCACTCCGCCAGCGCAAGGCCACGCCCGGCGAAATTGCCAGGCAGGCCGAGCATGGAGGTGTCTC
TACGGTGATCCGGCCGTATCTTGAGGCACTCACCGCCAATGGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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