Detailed information of TA system TA173840

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4524263..4525077
• Replicon: chromosome
• Accession: NZ_CP062243
• Organism: Escherichia coli strain AML003_ev03

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: IHN52_RS21815
• Protein ID: WP_001054376.1
• Coordinates: 4524820..4525077 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: IHN52_RS21810
• Protein ID: WP_001309181.1
• Coordinates: 4524263..4524808 (-)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IHN52_RS21780	4519954..4521267	-	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-
IHN52_RS21785	4521279..4521557	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
IHN52_RS21790	4521554..4522675	-	1122	WP_000010829.1	M42 family metallopeptidase	-
IHN52_RS21795	4522920..4523036	-	117	Protein_4240	VOC family protein	-
IHN52_RS21800	4523074..4523292	-	219	Protein_4241	hypothetical protein	-
IHN52_RS21805	4523461..4524207	-	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
IHN52_RS21810	4524263..4524808	-	546	WP_001309181.1	N-acetyltransferase	Antitoxin
IHN52_RS21815	4524820..4525077	-	258	WP_001054376.1	hypothetical protein	Toxin
IHN52_RS21820	4525454..4525699	-	246	Protein_4245	GNAT family N-acetyltransferase	-
IHN52_RS21825	4526069..4527055	+	987	WP_001323209.1	hypothetical protein	-
IHN52_RS21830	4527638..4528618	-	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
IHN52_RS21835	4528683..4529789	-	1107	WP_001309184.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	fimB / fimE	4479585..4533657	54072

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T173840 WP_001054376.1 NZ_CP062243:c4525077-4524820 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T173840 NZ_CP080346:c4586552-4586019 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT173840 WP_001309181.1 NZ_CP062243:c4524808-4524263 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT173840 NZ_CP080346:c4586829-4586563 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8