Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1424084..1424667 Replicon chromosome
Accession NZ_CP062231
Organism Rhizobium sp. TH2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IHQ71_RS07250 Protein ID WP_258161273.1
Coordinates 1424084..1424452 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IHQ71_RS07255 Protein ID WP_258161274.1
Coordinates 1424449..1424667 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHQ71_RS07230 (IHQ71_07200) 1419901..1420914 + 1014 WP_258161270.1 AraC family transcriptional regulator -
IHQ71_RS07235 (IHQ71_07205) 1420965..1421975 + 1011 WP_258161271.1 AraC family transcriptional regulator -
IHQ71_RS07240 (IHQ71_07210) 1422012..1422200 - 189 WP_258162765.1 hypothetical protein -
IHQ71_RS07245 (IHQ71_07215) 1422422..1424083 + 1662 WP_258161272.1 electron transfer flavoprotein-ubiquinone oxidoreductase -
IHQ71_RS07250 (IHQ71_07220) 1424084..1424452 - 369 WP_258161273.1 type II toxin-antitoxin system VapC family toxin Toxin
IHQ71_RS07255 (IHQ71_07225) 1424449..1424667 - 219 WP_258161274.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IHQ71_RS07260 (IHQ71_07230) 1424753..1426231 - 1479 WP_258161275.1 MDR family MFS transporter -
IHQ71_RS07265 (IHQ71_07235) 1426428..1427957 + 1530 WP_258161276.1 winged helix-turn-helix domain-containing protein -
IHQ71_RS07270 (IHQ71_07240) 1428682..1429299 + 618 WP_258161277.1 L,D-transpeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1416264..1424667 8403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13652.89 Da        Isoelectric Point: 6.0816

>T173624 WP_258161273.1 NZ_CP062231:c1424452-1424084 [Rhizobium sp. TH2]
VILLDTSVWIDHVSKNNDHLFELFEEGKILIHPFMIGEVALGSLRDHDKIIASLLEMPRPTVASEAEVLSLIRNRFLAGS
GIGYVDAQLLASTRLTPETMLWTRDKRLRRVAEAMGVAYALP

Download         Length: 369 bp

>T173624 NZ_CP080253:2343869-2344156 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8129.15 Da        Isoelectric Point: 6.3429

>AT173624 WP_258161274.1 NZ_CP062231:c1424667-1424449 [Rhizobium sp. TH2]
MRTTVTIDDELVSRAQEITGIEEKSALLNEALKRMIQRESAMRLARLGGSDPDAKAPPRRRWSEDGTRFGNE

Download         Length: 219 bp

>AT173624 NZ_CP080253:2343630-2343869 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References