Detailed information of TA system TA173617

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacT-ataR/DUF1778(antitoxin)
• Location: 3311403..3312160
• Replicon: chromosome
• Accession: NZ_CP062229
• Organism: Mesorhizobium onobrychidis strain OM4

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: IHQ72_RS16560
• Protein ID: WP_258123402.1
• Coordinates: 3311684..3312160 (+)
• Length: 159 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: IHQ72_RS16555
• Protein ID: WP_258123401.1
• Coordinates: 3311403..3311684 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IHQ72_RS16530 (IHQ72_16420)	3306875..3307855	+	981	WP_258123396.1	ABC transporter permease	-
IHQ72_RS16535 (IHQ72_16425)	3307852..3308838	+	987	WP_258123397.1	ABC transporter permease	-
IHQ72_RS16540 (IHQ72_16430)	3308868..3309398	+	531	WP_258123398.1	gluconokinase	-
IHQ72_RS16545 (IHQ72_16435)	3309437..3309886	-	450	WP_029351604.1	Rrf2 family transcriptional regulator	-
IHQ72_RS16550 (IHQ72_16440)	3310141..3311127	-	987	WP_258123400.1	sulfate ABC transporter substrate-binding protein	-
IHQ72_RS16555 (IHQ72_16445)	3311403..3311684	+	282	WP_258123401.1	DUF1778 domain-containing protein	Antitoxin
IHQ72_RS16560 (IHQ72_16450)	3311684..3312160	+	477	WP_258123402.1	GNAT family N-acetyltransferase	Toxin
IHQ72_RS16565 (IHQ72_16455)	3312203..3313243	-	1041	WP_258123403.1	sulfate/molybdate ABC transporter ATP-binding protein	-
IHQ72_RS16570 (IHQ72_16460)	3313259..3314143	-	885	WP_258123404.1	sulfate ABC transporter permease subunit CysW	-
IHQ72_RS16575 (IHQ72_16465)	3314136..3314987	-	852	WP_123152024.1	sulfate ABC transporter permease subunit CysT	-
IHQ72_RS16580 (IHQ72_16470)	3315019..3316047	-	1029	WP_258123406.1	sulfate ABC transporter substrate-binding protein	-
IHQ72_RS16585 (IHQ72_16475)	3316292..3316948	-	657	WP_258123408.1	M15 family metallopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (41-142)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-79)

Sequences

Toxin

Protein

• Length: 159 a.a.
• Molecular weight: 16811.34 Da
• Isoelectric Point: 8.5126

>T173617 WP_258123402.1 NZ_CP062229:3311684-3312160 [Mesorhizobium onobrychidis]
MLSAPTPLAENHDLELFQSGSESLDQWLRRRARANQISGASRTYVVTEGMRVVGCYCLSSGGLDLAEAPGAIRRNMPDPV
PMAVLGRLAVDAGWQGKGLGAALLQDAVLRTGHAATILGIRGIFVHAISAEAKAFYEHYGFAASPKNPMTLVLSLKAH

Nucleotide

• Length: 477 bp

>T173617 NZ_CP080253:c596661-596197 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10706.26 Da
• Isoelectric Point: 8.5142

>AT173617 WP_258123401.1 NZ_CP062229:3311403-3311684 [Mesorhizobium onobrychidis]
MTKTTPETHAKPVNLRIREDVRILIDRAAKIRGKTRSDFMIDAAYRAAEDTLLDQALIKVDPESYRHYLDILDEPPSGEG
FARLMNAPKPWQR

Nucleotide

• Length: 282 bp

>AT173617 NZ_CP080253:c596996-596661 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA