Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1139952..1140750 Replicon chromosome
Accession NZ_CP062228
Organism Escherichia coli strain UTI89

Toxin (Protein)


Gene name yeeV Uniprot ID Q1RDD2
Locus tag IFE20_RS05405 Protein ID WP_001094434.1
Coordinates 1140376..1140750 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag IFE20_RS05400 Protein ID WP_001552747.1
Coordinates 1139952..1140329 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFE20_RS05370 1136830..1137651 + 822 WP_001234585.1 DUF945 domain-containing protein -
IFE20_RS05375 1137651..1137896 + 246 WP_001164966.1 hypothetical protein -
IFE20_RS05380 1137990..1138463 + 474 WP_001542276.1 antirestriction protein -
IFE20_RS05385 1138479..1138955 + 477 WP_001186727.1 RadC family protein -
IFE20_RS05390 1139018..1139239 + 222 WP_000692315.1 DUF987 domain-containing protein -
IFE20_RS05395 1139258..1139902 + 645 WP_000086759.1 hypothetical protein -
IFE20_RS05400 1139952..1140329 + 378 WP_001552747.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
IFE20_RS05405 1140376..1140750 + 375 WP_001094434.1 TA system toxin CbtA family protein Toxin
IFE20_RS05410 1140747..1141238 + 492 WP_000976859.1 hypothetical protein -
IFE20_RS05415 1141250..1141447 + 198 WP_000839257.1 DUF957 domain-containing protein -
IFE20_RS05420 1141540..1142382 + 843 WP_001280460.1 DUF4942 domain-containing protein -
IFE20_RS05430 1142853..1143791 + 939 WP_000351298.1 glyoxylate/hydroxypyruvate reductase GhrA -
IFE20_RS05435 1143846..1144583 + 738 WP_000283664.1 zinc-binding phosphatase -
IFE20_RS05440 1144607..1145161 + 555 WP_001001909.1 molecular chaperone YcdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13921.82 Da        Isoelectric Point: 6.8517

>T173594 WP_001094434.1 NZ_CP062228:1140376-1140750 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T173594 NZ_CP080249:1970213-1970308 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13757.63 Da        Isoelectric Point: 6.3127

>AT173594 WP_001552747.1 NZ_CP062228:1139952-1140329 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRTGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp

>AT173594 NZ_CP080249:c1970393-1970336 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q1RDD2

Antitoxin

Source ID Structure

References