Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 88676..90299 Replicon plasmid p265k
Accession NZ_CP062226
Organism Salmonella enterica subsp. enterica serovar Goldcoast strain R18.1074

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag FC625_RS22490 Protein ID WP_000088046.1
Coordinates 88974..90299 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag FC625_RS22485 Protein ID WP_024136327.1
Coordinates 88676..88969 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FC625_RS22455 84218..84499 - 282 WP_000077926.1 hypothetical protein -
FC625_RS22460 84549..84740 - 192 WP_000398480.1 hypothetical protein -
FC625_RS22465 84964..86136 + 1173 WP_000952349.1 IS21 family transposase -
FC625_RS22470 86136..86933 + 798 WP_000544828.1 IS21-like element IS21 family helper ATPase IstB -
FC625_RS22475 86972..87307 - 336 WP_065311125.1 hypothetical protein -
FC625_RS22480 87680..88072 + 393 WP_000341066.1 hypothetical protein -
FC625_RS22485 88676..88969 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
FC625_RS22490 88974..90299 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
FC625_RS22495 90360..90566 + 207 WP_000134171.1 hypothetical protein -
FC625_RS22500 90668..91078 + 411 WP_000985911.1 hypothetical protein -
FC625_RS22505 91091..91906 + 816 WP_001572439.1 HNH endonuclease -
FC625_RS22510 92160..92585 + 426 WP_001043843.1 hypothetical protein -
FC625_RS22515 93134..93442 + 309 WP_001224687.1 hypothetical protein -
FC625_RS22520 93458..94315 + 858 WP_000784387.1 HNH endonuclease -
FC625_RS22525 94377..94580 + 204 WP_001194555.1 hypothetical protein -
FC625_RS22530 94922..95206 - 285 Protein_93 H-NS histone family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..265014 265014


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 56670.97 Da        Isoelectric Point: 13.4444

>T173587 WP_000088046.1 NZ_CP062226:88974-90299 [Salmonella enterica subsp. enterica serovar Goldcoast]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 1326 bp

>T173587 NZ_CP080247:3577715-3577993 [Escherichia sp. TM-G17TGC]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 12579.08 Da        Isoelectric Point: 12.7867

>AT173587 WP_024136327.1 NZ_CP062226:88676-88969 [Salmonella enterica subsp. enterica serovar Goldcoast]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKK

Download         Length: 294 bp

>AT173587 NZ_CP080247:3577452-3577712 [Escherichia sp. TM-G17TGC]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References