Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 87920..89543 Replicon plasmid p270k
Accession NZ_CP062224
Organism Salmonella enterica subsp. enterica serovar Goldcoast strain R18.1656

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag FC633_RS22490 Protein ID WP_000088046.1
Coordinates 88218..89543 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag FC633_RS22485 Protein ID WP_024136327.1
Coordinates 87920..88213 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FC633_RS22455 83462..83743 - 282 WP_000077926.1 hypothetical protein -
FC633_RS22460 83793..83984 - 192 WP_000398480.1 hypothetical protein -
FC633_RS22465 84208..85380 + 1173 WP_000952349.1 IS21 family transposase -
FC633_RS22470 85380..86177 + 798 WP_000544828.1 IS21-like element IS21 family helper ATPase IstB -
FC633_RS22475 86216..86551 - 336 WP_065311125.1 hypothetical protein -
FC633_RS22480 86924..87316 + 393 WP_000341066.1 hypothetical protein -
FC633_RS22485 87920..88213 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
FC633_RS22490 88218..89543 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
FC633_RS22495 89604..89810 + 207 WP_000134171.1 hypothetical protein -
FC633_RS22500 89912..90322 + 411 WP_000985911.1 hypothetical protein -
FC633_RS22505 90335..91150 + 816 WP_001572439.1 HNH endonuclease -
FC633_RS22510 91404..91829 + 426 WP_001043843.1 hypothetical protein -
FC633_RS22515 92378..92686 + 309 WP_001224687.1 hypothetical protein -
FC633_RS22520 92702..93559 + 858 WP_000784387.1 HNH endonuclease -
FC633_RS22525 93621..93824 + 204 WP_001194555.1 hypothetical protein -
FC633_RS22530 94166..94450 - 285 Protein_93 H-NS histone family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..270696 270696


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 56670.97 Da        Isoelectric Point: 13.4444

>T173586 WP_000088046.1 NZ_CP062224:88218-89543 [Salmonella enterica subsp. enterica serovar Goldcoast]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 1326 bp

>T173586 NZ_CP080247:c3571653-3571255 [Escherichia sp. TM-G17TGC]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 12579.08 Da        Isoelectric Point: 12.7867

>AT173586 WP_024136327.1 NZ_CP062224:87920-88213 [Salmonella enterica subsp. enterica serovar Goldcoast]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKK

Download         Length: 294 bp

>AT173586 NZ_CP080247:c3571949-3571656 [Escherichia sp. TM-G17TGC]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References