173582

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 4922537..4923042 Replicon chromosome
Accession NZ_CP062219
Organism Pseudomonas aeruginosa strain JT86

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag IGW72_RS22595 Protein ID WP_003121619.1
Coordinates 4922537..4922818 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag IGW72_RS22600 Protein ID WP_003112628.1
Coordinates 4922815..4923042 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGW72_RS22570 4917788..4919137 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
IGW72_RS22575 4919186..4919872 + 687 WP_003083762.1 FadR family transcriptional regulator -
IGW72_RS22580 4919973..4920707 + 735 WP_003115036.1 GntR family transcriptional regulator -
IGW72_RS22585 4920911..4921297 + 387 WP_014602345.1 aegerolysin family protein -
IGW72_RS22590 4921329..4922237 - 909 WP_003083769.1 LysR family transcriptional regulator -
IGW72_RS22595 4922537..4922818 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
IGW72_RS22600 4922815..4923042 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
IGW72_RS22605 4923218..4923838 - 621 WP_003101226.1 hypothetical protein -
IGW72_RS22610 4923939..4924439 + 501 WP_003101228.1 LEA type 2 family protein -
IGW72_RS22615 4924512..4924853 + 342 WP_003101229.1 alkylphosphonate utilization protein -
IGW72_RS22620 4924935..4926362 - 1428 WP_003083784.1 GABA permease -
IGW72_RS22625 4926531..4928024 - 1494 WP_016263977.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T173582 WP_003121619.1 NZ_CP062219:c4922818-4922537 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T173582 NZ_CP080247:2657730-2657837 [Escherichia sp. TM-G17TGC]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT173582 WP_003112628.1 NZ_CP062219:c4923042-4922815 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT173582 NZ_CP080247:c2657683-2657617 [Escherichia sp. TM-G17TGC]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References