Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2846622..2847453 Replicon chromosome
Accession NZ_CP062211
Organism Escherichia coli strain L3Cip3

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag IFO96_RS13845 Protein ID WP_000854814.1
Coordinates 2847079..2847453 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag IFO96_RS13840 Protein ID WP_001285585.1
Coordinates 2846622..2846990 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFO96_RS13810 2843526..2843981 + 456 WP_000581504.1 hypothetical protein -
IFO96_RS13815 2844060..2844293 + 234 WP_001119729.1 DUF905 family protein -
IFO96_RS13820 2844393..2845211 + 819 WP_032250973.1 DUF945 domain-containing protein -
IFO96_RS13825 2845293..2845772 + 480 WP_000860087.1 antirestriction protein -
IFO96_RS13830 2845788..2846264 + 477 WP_001186726.1 RadC family protein -
IFO96_RS13835 2846327..2846548 + 222 WP_000692323.1 DUF987 domain-containing protein -
IFO96_RS13840 2846622..2846990 + 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
IFO96_RS13845 2847079..2847453 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
IFO96_RS13850 2847450..2847644 + 195 WP_000988600.1 hypothetical protein -
IFO96_RS13855 2847657..2847770 + 114 WP_001161660.1 DUF957 domain-containing protein -
IFO96_RS13860 2848059..2848187 - 129 Protein_2707 transposase domain-containing protein -
IFO96_RS13865 2848259..2848441 + 183 WP_001016348.1 hypothetical protein -
IFO96_RS13870 2848542..2848871 - 330 WP_000450409.1 DUF496 family protein -
IFO96_RS13875 2849043..2850101 - 1059 WP_001200891.1 FUSC family protein -
IFO96_RS13880 2850299..2850772 - 474 WP_001105389.1 DNA gyrase inhibitor SbmC -
IFO96_RS13885 2850891..2852057 - 1167 WP_000830150.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T173548 WP_000854814.1 NZ_CP062211:2847079-2847453 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T173548 NZ_CP080246:991357-991764 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT173548 WP_001285585.1 NZ_CP062211:2846622-2846990 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT173548 NZ_CP080246:991110-991376 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTTTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References