Detailed information of TA system TA173539

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2342324..2343912
• Replicon: chromosome
• Accession: NZ_CP062211
• Organism: Escherichia coli strain L3Cip3

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: E0IX85
• Locus tag: IFO96_RS11285
• Protein ID: WP_001125454.1
• Coordinates: 2342324..2343646 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: IFO96_RS11290
• Protein ID: WP_001296726.1
• Coordinates: 2343646..2343912 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IFO96_RS11270	2339738..2340448	-	711	WP_001195166.1	fimbria/pilus periplasmic chaperone	-
IFO96_RS11275	2340809..2341372	-	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
IFO96_RS11280	2341804..2342012	-	209	Protein_2204	helix-turn-helix transcriptional regulator	-
IFO96_RS11285	2342324..2343646	-	1323	WP_001125454.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
IFO96_RS11290	2343646..2343912	-	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
IFO96_RS11295	2344121..2345521	-	1401	WP_001083595.1	autotransporter outer membrane beta-barrel domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimA	2329033..2344093	15060

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49307.90 Da
• Isoelectric Point: 8.8753

>T173539 WP_001125454.1 NZ_CP062211:c2343646-2342324 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T173539 NZ_CP080242:517180-517437 [Polymorphobacter sp. PAMC 29334]
TTGTCGCTTAGCCGTGCGGGAGAGGCTGGGCTCGAGCAATTACAGGCTTTGCTAGACACGCTGAAGATTGAGACCGTGCC
GGTCTCGGCCAACCACGCCAGCCTTGCAATCGACGCCTTCCGACGCTTTGGCAAGGGACGGCATTCAGCGGGCCTCAACT
TCGGCGATTGCTTCTTATATGCGCTCGCCAAGGCAACAGGCGAGCCAGTGTTATTCAAGGGCGAGGTCTTTTCACACACT
GACATTGAGCAGGTCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT173539 WP_001296726.1 NZ_CP062211:c2343912-2343646 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT173539 NZ_CP080242:516796-517053 [Polymorphobacter sp. PAMC 29334]
ATGGCGCTGAGTGTGAAAGATCGAGAAACCGATAGCCTCGCCCGCCAGGTGACGAGCATGACCGGTGAGACGCTGACTGA
AGCGGTGCGCGGTGCTCTTCGGCTGCGGTTGCGCGATGAGCAGCTCAAACGCGGCGAGCGGCCTTGGGACGACCAGGCAA
TTGACGCGATCCTCGAGCGGTTCAACGCGCTTCCTTTACTCGATCAGCGATTTGACGATGAGATCCTGGGCTACGACGAA
CACGGCCTGTCGTCCTGA

Structures

Toxin

• AlphaFold DB: E0IX85