Detailed information of TA system TA173536

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1845960..1846804
• Replicon: chromosome
• Accession: NZ_CP062211
• Organism: Escherichia coli strain L3Cip3

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B1LJY4
• Locus tag: IFO96_RS08845
• Protein ID: WP_000854686.1
• Coordinates: 1846421..1846804 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A8E0J1S3
• Locus tag: IFO96_RS08840
• Protein ID: WP_001285602.1
• Coordinates: 1845960..1846340 (+)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IFO96_RS08805	1842208..1842663	+	456	WP_000581506.1	hypothetical protein	-
IFO96_RS08810	1842764..1842972	+	209	Protein_1714	DUF905 family protein	-
IFO96_RS08815	1843073..1843894	+	822	WP_001761104.1	DUF945 domain-containing protein	-
IFO96_RS08820	1843986..1844471	+	486	WP_000214307.1	antirestriction protein	-
IFO96_RS08825	1844487..1844963	+	477	WP_001186726.1	RadC family protein	-
IFO96_RS08830	1845026..1845247	+	222	WP_000692298.1	DUF987 domain-containing protein	-
IFO96_RS08835	1845266..1845949	+	684	WP_192301359.1	antitoxin of toxin-antitoxin stability system	-
IFO96_RS08840	1845960..1846340	+	381	WP_001285602.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
IFO96_RS08845	1846421..1846804	+	384	WP_000854686.1	TA system toxin CbtA family protein	Toxin
IFO96_RS08850	1846801..1847289	+	489	WP_032180032.1	hypothetical protein	-
IFO96_RS08855	1847306..1847503	+	198	WP_000839253.1	DUF957 domain-containing protein	-
IFO96_RS08860	1847588..1848429	+	842	Protein_1724	DUF4942 domain-containing protein	-
IFO96_RS08870	1848900..1849838	+	939	WP_000351317.1	glyoxylate/hydroxypyruvate reductase GhrA	-
IFO96_RS08875	1849893..1850630	+	738	WP_000283664.1	zinc-binding phosphatase	-
IFO96_RS08880	1850654..1851208	+	555	WP_001001902.1	molecular chaperone YcdY	-
IFO96_RS08885	1851310..1851801	+	492	WP_001297187.1	DUF1097 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	csgG / csgF / csgE / csgD / csgB / csgA / csgC	1817474..1857366	39892

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-113)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14272.28 Da
• Isoelectric Point: 6.8614

>T173536 WP_000854686.1 NZ_CP062211:1846421-1846804 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Nucleotide

• Length: 384 bp

>T173536 NZ_CP080238:c263552-263274 [Vibrio sp. ED002]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGAGGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTACTCATTATTCCTGAGATTTCGATGATTATCTCTTACTGGGTCGAGGGCGATATCATTCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13938.69 Da
• Isoelectric Point: 5.0823

>AT173536 WP_001285602.1 NZ_CP062211:1845960-1846340 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT173536 NZ_CP080238:c263833-263549 [Vibrio sp. ED002]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAACACCAAACGGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA