Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 993261..993879 Replicon chromosome
Accession NZ_CP062211
Organism Escherichia coli strain L3Cip3

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag IFO96_RS04840 Protein ID WP_001291435.1
Coordinates 993261..993479 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag IFO96_RS04845 Protein ID WP_000344800.1
Coordinates 993505..993879 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFO96_RS04805 988551..989123 + 573 WP_000779826.1 lipoprotein -
IFO96_RS04810 989154..989465 - 312 WP_000409911.1 MGMT family protein -
IFO96_RS04820 989844..990197 + 354 WP_000878141.1 DUF1428 family protein -
IFO96_RS04825 990239..991789 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
IFO96_RS04830 991953..992423 - 471 WP_000136192.1 YlaC family protein -
IFO96_RS04835 992539..993090 - 552 WP_000102564.1 maltose O-acetyltransferase -
IFO96_RS04840 993261..993479 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
IFO96_RS04845 993505..993879 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
IFO96_RS04850 994425..997574 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
IFO96_RS04855 997597..998790 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T173534 WP_001291435.1 NZ_CP062211:c993479-993261 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T173534 NZ_CP080238:c244671-244393 [Vibrio sp. ED002]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTATTGGGTCGAGGGTGATATCATCAGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTATGGATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT173534 WP_000344800.1 NZ_CP062211:c993879-993505 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT173534 NZ_CP080238:c244952-244668 [Vibrio sp. ED002]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TTTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCGGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References