Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/DUF4065(antitoxin) |
| Location | 4767812..4768856 | Replicon | chromosome |
| Accession | NZ_CP062204 | ||
| Organism | Escherichia coli strain C311 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | IG172_RS23305 | Protein ID | WP_192291974.1 |
| Coordinates | 4767812..4768360 (-) | Length | 183 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | A0A839B6W4 |
| Locus tag | IG172_RS23310 | Protein ID | WP_000287252.1 |
| Coordinates | 4768383..4768856 (-) | Length | 158 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IG172_RS23260 | 4763041..4763865 | + | 825 | WP_000081319.1 | YfdQ family protein | - |
| IG172_RS23265 | 4763994..4764530 | + | 537 | WP_000008178.1 | 5'-deoxynucleotidase | - |
| IG172_RS23270 | 4764521..4764871 | + | 351 | WP_001242740.1 | hypothetical protein | - |
| IG172_RS23275 | 4764868..4765353 | + | 486 | WP_000145672.1 | class I SAM-dependent methyltransferase | - |
| IG172_RS23280 | 4765350..4765949 | + | 600 | WP_074512079.1 | ead/Ea22-like family protein | - |
| IG172_RS23285 | 4765951..4766142 | + | 192 | WP_001014290.1 | hypothetical protein | - |
| IG172_RS23290 | 4766145..4766897 | + | 753 | WP_001094867.1 | DUF551 domain-containing protein | - |
| IG172_RS23295 | 4766897..4767469 | + | 573 | WP_001061339.1 | 3'-5' exoribonuclease | - |
| IG172_RS23300 | 4767506..4767778 | + | 273 | WP_001093911.1 | pyocin activator PrtN family protein | - |
| IG172_RS23305 | 4767812..4768360 | - | 549 | WP_192291974.1 | hypothetical protein | Toxin |
| IG172_RS23310 | 4768383..4768856 | - | 474 | WP_000287252.1 | SocA family protein | Antitoxin |
| IG172_RS23315 | 4769143..4769265 | - | 123 | WP_001300034.1 | hypothetical protein | - |
| IG172_RS23320 | 4769629..4770652 | - | 1024 | Protein_4573 | DUF2713 family protein | - |
| IG172_RS23325 | 4770970..4771485 | + | 516 | WP_001295691.1 | zinc uptake transcriptional repressor Zur | - |
| IG172_RS23330 | 4771527..4771736 | - | 210 | WP_001030593.1 | CsbD family protein | - |
| IG172_RS23335 | 4771852..4773177 | - | 1326 | WP_001295692.1 | MATE family efflux transporter DinF | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4718740..4773858 | 55118 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 183 a.a. Molecular weight: 19847.26 Da Isoelectric Point: 4.5029
>T173521 WP_192291974.1 NZ_CP062204:c4768360-4767812 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEAEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVLFMSCWCLFVAGMFVSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDGDKEK
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEAEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVLFMSCWCLFVAGMFVSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDGDKEK
Download Length: 549 bp
>T173521 NZ_CP080235:2290539-2290850 [Escherichia coli O139:H1]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAATAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAATAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA
Antitoxin
Download Length: 158 a.a. Molecular weight: 17298.80 Da Isoelectric Point: 8.4143
>AT173521 WP_000287252.1 NZ_CP062204:c4768856-4768383 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL
Download Length: 474 bp
>AT173521 NZ_CP080235:2290847-2291266 [Escherichia coli O139:H1]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGATACTAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAATAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCGTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGATACTAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAATAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCGTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|