Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 951664..952318 Replicon chromosome
Accession NZ_CP062204
Organism Escherichia coli strain C311

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag IG172_RS04670 Protein ID WP_000244777.1
Coordinates 951911..952318 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag IG172_RS04665 Protein ID WP_000354046.1
Coordinates 951664..951930 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG172_RS04640 946833..947576 + 744 WP_000951964.1 SDR family oxidoreductase -
IG172_RS04645 947633..949066 - 1434 WP_001307385.1 6-phospho-beta-glucosidase BglA -
IG172_RS04650 949111..949422 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
IG172_RS04655 949586..950245 + 660 WP_000250274.1 hemolysin III family protein -
IG172_RS04660 950441..951421 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
IG172_RS04665 951664..951930 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
IG172_RS04670 951911..952318 + 408 WP_000244777.1 toxin CptA Toxin
IG172_RS04675 952358..952879 - 522 WP_001055874.1 flavodoxin FldB -
IG172_RS04680 952991..953887 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
IG172_RS04685 953912..954622 + 711 WP_000715208.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IG172_RS04690 954628..956361 + 1734 WP_000813223.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T173502 WP_000244777.1 NZ_CP062204:951911-952318 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T173502 NZ_CP080233:c2625374-2625087 [Escherichia coli O139:H1]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT173502 WP_000354046.1 NZ_CP062204:951664-951930 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT173502 NZ_CP080233:c2625613-2625374 [Escherichia coli O139:H1]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References