Detailed information of TA system TA173492

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 3284588..3285293
• Replicon: chromosome
• Accession: NZ_CP062203
• Organism: Escherichia coli strain K_EC180

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A3A6SJV3
• Locus tag: IGX36_RS16145
• Protein ID: WP_063085620.1
• Coordinates: 3284588..3284974 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: IGX36_RS16150
• Protein ID: WP_001280945.1
• Coordinates: 3284964..3285293 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IGX36_RS16125	3280592..3281218	+	627	WP_001314584.1	glutathione S-transferase GstB	-
IGX36_RS16130	3281215..3282330	-	1116	WP_063085618.1	aldose sugar dehydrogenase YliI	-
IGX36_RS16135	3282441..3282824	-	384	WP_000497137.1	biofilm formation regulator BssR	-
IGX36_RS16140	3283037..3284362	+	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
IGX36_RS16145	3284588..3284974	+	387	WP_063085620.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IGX36_RS16150	3284964..3285293	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
IGX36_RS16155	3285363..3286691	-	1329	WP_000086873.1	GGDEF domain-containing protein	-
IGX36_RS16160	3286699..3289047	-	2349	WP_021523051.1	EAL domain-containing protein	-
IGX36_RS16165	3289225..3290136	-	912	WP_001236019.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14280.45 Da
• Isoelectric Point: 9.9296

>T173492 WP_063085620.1 NZ_CP062203:3284588-3284974 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSTKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T173492 NZ_CP080233:1066643-1067041 [Escherichia coli O139:H1]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTATTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT173492 WP_001280945.1 NZ_CP062203:3284964-3285293 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT173492 NZ_CP080233:1066347-1066640 [Escherichia coli O139:H1]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAACTGGTGAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Toxin

• AlphaFold DB: A0A3A6SJV3