Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3011893..3012727 Replicon chromosome
Accession NZ_CP062203
Organism Escherichia coli strain K_EC180

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3S7R4W2
Locus tag IGX36_RS14835 Protein ID WP_063085447.1
Coordinates 3011893..3012270 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2J4HRK6
Locus tag IGX36_RS14840 Protein ID WP_001354276.1
Coordinates 3012359..3012727 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGX36_RS14800 3007277..3008110 + 834 WP_001189321.1 curli production assembly/transport protein CsgG -
IGX36_RS14805 3008175..3008666 - 492 WP_032140678.1 DUF1097 domain-containing protein -
IGX36_RS14810 3008768..3009322 - 555 WP_063085449.1 molecular chaperone YcdY -
IGX36_RS14815 3009346..3010083 - 738 WP_000283664.1 zinc-binding phosphatase -
IGX36_RS14820 3010138..3011076 - 939 WP_001357083.1 glyoxylate/hydroxypyruvate reductase GhrA -
IGX36_RS14830 3011546..3011806 - 261 Protein_2905 DUF4942 domain-containing protein -
IGX36_RS14835 3011893..3012270 - 378 WP_063085447.1 type IV toxin-antitoxin system toxin CbtA Toxin
IGX36_RS14840 3012359..3012727 - 369 WP_001354276.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
IGX36_RS14845 3012777..3012983 - 207 Protein_2908 antitoxin of the YeeV-YeeU toxin-antitoxin system -
IGX36_RS14850 3012984..3013280 - 297 Protein_2909 antirestriction protein -
IGX36_RS14855 3013249..3014121 - 873 Protein_2910 autotransporter adhesin Ag43 -
IGX36_RS14860 3014494..3015366 - 873 WP_053271975.1 GTPase family protein -
IGX36_RS14865 3015630..3017186 + 1557 WP_086186061.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13908.94 Da        Isoelectric Point: 8.5222

>T173491 WP_063085447.1 NZ_CP062203:c3012270-3011893 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNNTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T173491 NZ_CP080233:722928-723215 [Escherichia coli O139:H1]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13649.47 Da        Isoelectric Point: 7.0261

>AT173491 WP_001354276.1 NZ_CP062203:c3012727-3012359 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLSSCGYVYLAVYPTPKMKN

Download         Length: 369 bp

>AT173491 NZ_CP080233:723202-723504 [Escherichia coli O139:H1]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S7R4W2

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4HRK6

References