Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3742465..3743138 Replicon chromosome
Accession NZ_CP062167
Organism Aureimonas sp. OT7

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IGS74_RS17955 Protein ID WP_192387961.1
Coordinates 3742465..3742887 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IGS74_RS17960 Protein ID WP_192387963.1
Coordinates 3742884..3743138 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGS74_RS17925 3738117..3738386 - 270 WP_192387950.1 helix-turn-helix domain-containing protein -
IGS74_RS17930 3738848..3739135 + 288 WP_192387952.1 DUF2285 domain-containing protein -
IGS74_RS17935 3739148..3739789 - 642 WP_192391874.1 DUF2285 domain-containing protein -
IGS74_RS17940 3740239..3741084 - 846 WP_192387955.1 DUF945 domain-containing protein -
IGS74_RS17945 3741426..3741743 - 318 WP_192387957.1 DUF736 domain-containing protein -
IGS74_RS17950 3741996..3742304 + 309 WP_192387959.1 hypothetical protein -
IGS74_RS17955 3742465..3742887 - 423 WP_192387961.1 type II toxin-antitoxin system VapC family toxin Toxin
IGS74_RS17960 3742884..3743138 - 255 WP_192387963.1 plasmid stabilization protein Antitoxin
IGS74_RS17965 3743215..3743631 - 417 WP_192387965.1 hypothetical protein -
IGS74_RS17970 3743847..3745955 - 2109 WP_192387967.1 ParB/RepB/Spo0J family partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14917.81 Da        Isoelectric Point: 4.6987

>T173474 WP_192387961.1 NZ_CP062167:c3742887-3742465 [Aureimonas sp. OT7]
MIVLDTNVVSEAMKPEPDSAVRDWLDEQAAETLYLSSVTVAELLFGIGALPDGRRKQKLAATLDEHLALFDGRILPFDTD
AARHYADLAVAARNAGKGFPTPDGYIAAIATAHGFSVATRDASAFNAAGVPVIDPWTARH

Download         Length: 423 bp

>T173474 NZ_CP080223:3665166-3665384 [Escherichia coli O141:H4]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9206.46 Da        Isoelectric Point: 10.9254

>AT173474 WP_192387963.1 NZ_CP062167:c3743138-3742884 [Aureimonas sp. OT7]
MPAVTIRNLSEEAHRALKVRAAHHGRSAEAEMRNILEAAVRPADRLRIGSALSALSRKAGLTNADFESVEQARDRTPAKP
MSFE

Download         Length: 255 bp

>AT173474 NZ_CP080223:3664766-3665140 [Escherichia coli O141:H4]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References