Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PHA01976(antitoxin)
Location 2967050..2967640 Replicon chromosome
Accession NZ_CP062167
Organism Aureimonas sp. OT7

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag IGS74_RS14115 Protein ID WP_192386956.1
Coordinates 2967050..2967298 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag IGS74_RS14120 Protein ID WP_192386958.1
Coordinates 2967311..2967640 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGS74_RS14090 2962203..2963597 - 1395 WP_192386952.1 glutathione-disulfide reductase -
IGS74_RS14095 2963681..2964178 - 498 WP_039193280.1 DUF2059 domain-containing protein -
IGS74_RS14100 2964308..2965003 - 696 WP_039193277.1 ribose-5-phosphate isomerase RpiA -
IGS74_RS14105 2965163..2965876 + 714 WP_192386954.1 HAD hydrolase-like protein -
IGS74_RS14115 2967050..2967298 + 249 WP_192386956.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IGS74_RS14120 2967311..2967640 + 330 WP_192386958.1 helix-turn-helix transcriptional regulator Antitoxin
IGS74_RS14125 2968510..2969097 - 588 WP_192386960.1 alkylhydroperoxidase -
IGS74_RS14130 2969353..2970342 + 990 WP_192386962.1 hypothetical protein -
IGS74_RS14135 2970434..2971939 - 1506 WP_192386964.1 tripartite tricarboxylate transporter permease -
IGS74_RS14140 2971945..2972376 - 432 WP_192386966.1 tripartite tricarboxylate transporter TctB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-78)

Antitoxin

Cro/C1-type helix-turn-helix domain

(54-108)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9135.63 Da        Isoelectric Point: 10.9911

>T173473 WP_192386956.1 NZ_CP062167:2967050-2967298 [Aureimonas sp. OT7]
MKEITYRPAAVKALRRMPANTARRIVGKIETYAADPSSQANNIKKLQGRDGIRLRLGDWRVIMQDGVVLDVLNIGPRGGV
YD

Download         Length: 249 bp

>T173473 NZ_CP080223:2925486-2925773 [Escherichia coli O141:H4]
ATGTTACCCATTTTATGGCTACCATCTGCTCGCGATGATTTGCGTCAGATCGTAGCCTATATTGCCAAGGAAAATATTCC
TGCAGCACGCAGGCTAAAAATACGTATTGAAACGTCTGTTTTAGCCCTCTCCGAGCATCCATATCTATATCCGCCAAGTG
ATCGAGTATCCGGTTTGCGGGAAATTGTGGTTCACCCTAATTATATCGTTTTATACCGAGTAGCAGCTTCAAGCATTGAA
ATTGCAAATATTGTGCATGCCCGCCGACAATTTCCCTTCCCTATCTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11901.43 Da        Isoelectric Point: 4.2790

>AT173473 WP_192386958.1 NZ_CP062167:2967311-2967640 [Aureimonas sp. OT7]
MNEMVTIEKTEYERLLNAADDLADIIAYDRAMGDGGESIPAEFVKRMIDGESPLRVYRDLRGLTQAQLSESAGVNRVQIA
DIEAGRKSGSVDTIRKLATALSVSIDDLV

Download         Length: 330 bp

>AT173473 NZ_CP080223:2925295-2925486 [Escherichia coli O141:H4]
ATGAGTACAGCCCTTTCTCCGATAGTTTCAGAGTTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCGC
TAAAGTGACGTCAAGCCTTGCAGACCCTCGCCCCTCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAGGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References