Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-couple_hipB
Location 2235001..2235641 Replicon chromosome
Accession NZ_CP062167
Organism Aureimonas sp. OT7

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag IGS74_RS10755 Protein ID WP_192386117.1
Coordinates 2235384..2235641 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag IGS74_RS10750 Protein ID WP_192386116.1
Coordinates 2235001..2235372 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGS74_RS10715 2230216..2231196 + 981 WP_192386112.1 ketoacyl-ACP synthase III -
IGS74_RS10720 2231301..2231636 + 336 WP_039190270.1 integration host factor subunit alpha -
IGS74_RS10725 2231652..2232155 + 504 WP_192386113.1 MerR family transcriptional regulator -
IGS74_RS10730 2232286..2233101 + 816 WP_039190274.1 MipA/OmpV family protein -
IGS74_RS10735 2233139..2234191 + 1053 WP_192391741.1 MBL fold metallo-hydrolase -
IGS74_RS10740 2234366..2234695 + 330 WP_192386114.1 DoxX family protein -
IGS74_RS10745 2234753..2235004 + 252 WP_192386115.1 hypothetical protein -
IGS74_RS10750 2235001..2235372 - 372 WP_192386116.1 helix-turn-helix domain-containing protein Antitoxin
IGS74_RS10755 2235384..2235641 - 258 WP_192386117.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
IGS74_RS10760 2236008..2237225 + 1218 WP_192386118.1 tyrosine-type recombinase/integrase -
IGS74_RS10765 2237222..2237935 + 714 WP_192386119.1 hypothetical protein -
IGS74_RS10770 2237964..2238218 + 255 WP_192386120.1 AlpA family phage regulatory protein -
IGS74_RS10775 2238215..2238433 + 219 WP_192386121.1 hypothetical protein -
IGS74_RS10780 2238430..2238969 + 540 WP_192386122.1 hypothetical protein -
IGS74_RS10785 2239145..2239897 + 753 WP_192386123.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Cro/C1-type helix-turn-helix domain

(71-122)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9587.14 Da        Isoelectric Point: 11.0174

>T173472 WP_192386117.1 NZ_CP062167:c2235641-2235384 [Aureimonas sp. OT7]
MKAISYTTRALRSLSRMPRNVATRIQAKVEQFAADPASLANNVKALKGEISGTYRLRVGDYRVIFNEHGVVLVVLKVGHR
RDIYE

Download         Length: 258 bp

>T173472 NZ_CP080223:2824274-2824381 [Escherichia coli O141:H4]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13190.98 Da        Isoelectric Point: 4.6168

>AT173472 WP_192386116.1 NZ_CP062167:c2235372-2235001 [Aureimonas sp. OT7]
MSVQYITTPAGETLAVLPKSEYEALIERLEDIVDSAAAADTLARINAGEEELIPAAVVKRIVDGENKVRVWREHRGMSVT
ALAKASGLSQAYVSQIESGARAARPDKRAAIAEALNLAIDDLF

Download         Length: 372 bp

>AT173472 NZ_CP080223:c2824227-2824161 [Escherichia coli O141:H4]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References