Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 5127293..5127928 Replicon chromosome
Accession NZ_CP062165
Organism Paenibacillus sp. JNUCC-31

Toxin (Protein)


Gene name mazF Uniprot ID W4B4V0
Locus tag JNUCC31_RS22155 Protein ID WP_024630714.1
Coordinates 5127578..5127928 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2W6NI96
Locus tag JNUCC31_RS22150 Protein ID WP_024630715.1
Coordinates 5127293..5127574 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNUCC31_RS22135 5122370..5123866 - 1497 WP_192273240.1 serine hydrolase -
JNUCC31_RS22140 5124160..5125374 + 1215 WP_192264803.1 outer membrane lipoprotein-sorting protein -
JNUCC31_RS22145 5125844..5127031 + 1188 WP_192264805.1 alanine racemase -
JNUCC31_RS22150 5127293..5127574 + 282 WP_024630715.1 ribbon-helix-helix protein, CopG family Antitoxin
JNUCC31_RS22155 5127578..5127928 + 351 WP_024630714.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JNUCC31_RS22160 5128162..5130351 + 2190 WP_192264807.1 alpha-galactosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-46)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12778.77 Da        Isoelectric Point: 5.1184

>T173471 WP_024630714.1 NZ_CP062165:5127578-5127928 [Paenibacillus sp. JNUCC-31]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTCIVAAITAQIQKAKLPTHVEIDAAAHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMKLVNEALQISLGLIDF

Download         Length: 351 bp

>T173471 NZ_CP080223:2823739-2823846 [Escherichia coli O141:H4]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10723.33 Da        Isoelectric Point: 5.8649

>AT173471 WP_024630715.1 NZ_CP062165:5127293-5127574 [Paenibacillus sp. JNUCC-31]
VANLQNTKRIMISLPDYLLQEVDGIVALENSNRSELIRQAMKLYLTERKKRYIRESMQRGYMEMAKINLTMASEAFHAEE
DADSTLDRLVSGV

Download         Length: 282 bp

>AT173471 NZ_CP080223:c2823692-2823626 [Escherichia coli O141:H4]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W4B4V0

Antitoxin

Source ID Structure
AlphaFold DB A0A2W6NI96

References