Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/PRK09907-MazE
Location 1539039..1539637 Replicon chromosome
Accession NZ_CP062165
Organism Paenibacillus sp. JNUCC-31

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag JNUCC31_RS06495 Protein ID WP_192269740.1
Coordinates 1539039..1539374 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag JNUCC31_RS06500 Protein ID WP_192272819.1
Coordinates 1539371..1539637 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNUCC31_RS06485 1534696..1535574 - 879 WP_192269734.1 amidohydrolase family protein -
JNUCC31_RS06490 1535561..1538734 - 3174 WP_192269737.1 GNAT family N-acetyltransferase -
JNUCC31_RS06495 1539039..1539374 - 336 WP_192269740.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JNUCC31_RS06500 1539371..1539637 - 267 WP_192272819.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JNUCC31_RS06505 1540092..1540970 - 879 WP_192269743.1 EamA family transporter RarD -
JNUCC31_RS06510 1541099..1541542 - 444 WP_192269746.1 GNAT family N-acetyltransferase -
JNUCC31_RS06515 1541737..1542117 + 381 WP_192269749.1 hypothetical protein -
JNUCC31_RS06520 1542075..1542548 - 474 WP_192269752.1 DinB family protein -
JNUCC31_RS06525 1542713..1543198 - 486 WP_192269755.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-109)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12504.33 Da        Isoelectric Point: 5.6269

>T173470 WP_192269740.1 NZ_CP062165:c1539374-1539039 [Paenibacillus sp. JNUCC-31]
MIIPKRGDLIWLDFDPQAGHEQAGRRPAIVLSEHEFNEVTGFAVVCPITSQAKDYPFEVTLPEDLPFSGFVLTDQLKSLD
VRQRRIQIAGHAEPTSEFMKSVLRNVRSILA

Download         Length: 336 bp

>T173470 NZ_CP080223:c2526369-2526193 [Escherichia coli O141:H4]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10009.37 Da        Isoelectric Point: 5.1801

>AT173470 WP_192272819.1 NZ_CP062165:c1539637-1539371 [Paenibacillus sp. JNUCC-31]
MTTATLSKWGNSSAIRIPNQLLKRLNLEEGSEIEILVTADNELLLRPKTKPVESNEELRNHLKTLLSKVKQDTRHEEIDF
GTEGNELL

Download         Length: 267 bp

>AT173470 NZ_CP080223:c2526147-2525731 [Escherichia coli O141:H4]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References