Detailed information of TA system TA173467

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 74127..74671
• Replicon: chromosome
• Accession: NZ_CP062164
• Organism: Xanthomonas arboricola pv. corylina strain A7

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ICA18_RS00265
• Protein ID: WP_228960823.1
• Coordinates: 74402..74671 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2N7V9L6
• Locus tag: ICA18_RS00260
• Protein ID: WP_016902922.1
• Coordinates: 74127..74384 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICA18_RS00245 (ICA18_00245)	69235..70743	-	1509	WP_016904858.1	ribonuclease H-like domain-containing protein	-
ICA18_RS00250 (ICA18_00250)	70740..73235	-	2496	WP_016904859.1	DEAD/DEAH box helicase	-
ICA18_RS00255 (ICA18_00255)	73409..74071	+	663	WP_039511099.1	hemolysin III family protein	-
ICA18_RS00260 (ICA18_00260)	74127..74384	+	258	WP_016902922.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ICA18_RS00265 (ICA18_00265)	74402..74671	+	270	WP_228960823.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ICA18_RS00270 (ICA18_00270)	74790..75311	-	522	WP_016902924.1	hypothetical protein	-
ICA18_RS00275 (ICA18_00275)	75481..75834	-	354	WP_016902925.1	helix-turn-helix domain-containing protein	-
ICA18_RS00280 (ICA18_00280)	75857..76075	+	219	WP_230673957.1	YciI family protein	-
ICA18_RS00285 (ICA18_00285)	76235..77326	-	1092	WP_039815611.1	ATP-grasp fold amidoligase family protein	-
ICA18_RS00290 (ICA18_00290)	77783..78496	+	714	WP_053046149.1	hypothetical protein	-
ICA18_RS00295 (ICA18_00295)	78507..79400	-	894	WP_053046150.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-80)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10221.75 Da
• Isoelectric Point: 10.1539

>T173467 WP_228960823.1 NZ_CP062164:74402-74671 [Xanthomonas arboricola pv. corylina]
VADLDAIADYIALEDAAAAAALVRRVFAHVEQLAEHPESGSRPQELKRSRYRQIVEPPCRVFYRVDGQRVVVVHVMRSER
LLRKNRLSR

Nucleotide

• Length: 270 bp

>T173467 NZ_CP080223:1879469-1879723 [Escherichia coli O141:H4]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9704.23 Da
• Isoelectric Point: 8.6056

>AT173467 WP_016902922.1 NZ_CP062164:74127-74384 [Xanthomonas arboricola pv. corylina]
MRTELVTTLKRQATELLADVERDKEPILITQHGLPSAYLVDVASYERMQQRMAILEGIARGEMAVAEGRSLSHEQAKQRL
ARWLK

Nucleotide

• Length: 258 bp

>AT173467 NZ_CP080223:1879221-1879472 [Escherichia coli O141:H4]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCATAGGAACAGAAAAGGAC
ATTATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A2N7V9L6