173466

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 2098693..2099332 Replicon chromosome
Accession NZ_CP062163
Organism Brevibacillus sp. JNUCC-41

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag JNUCC41_RS10405 Protein ID WP_034306610.1
Coordinates 2098982..2099332 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag JNUCC41_RS10400 Protein ID WP_034306380.1
Coordinates 2098693..2098974 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNUCC41_RS10380 2094827..2095417 - 591 WP_192207528.1 rhomboid family intramembrane serine protease -
JNUCC41_RS10385 2095526..2095876 + 351 WP_192207529.1 holo-ACP synthase -
JNUCC41_RS10390 2096121..2097125 + 1005 WP_192207530.1 outer membrane lipoprotein carrier protein LolA -
JNUCC41_RS10395 2097375..2098532 + 1158 WP_192208121.1 alanine racemase -
JNUCC41_RS10400 2098693..2098974 + 282 WP_034306380.1 antitoxin EndoAI Antitoxin
JNUCC41_RS10405 2098982..2099332 + 351 WP_034306610.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JNUCC41_RS10410 2099753..2100580 + 828 WP_192207531.1 STAS domain-containing protein -
JNUCC41_RS10415 2100583..2100939 + 357 WP_076373142.1 STAS domain-containing protein -
JNUCC41_RS10420 2100943..2101344 + 402 WP_048682056.1 anti-sigma regulatory factor -
JNUCC41_RS10425 2101354..2102364 + 1011 WP_192207532.1 PP2C family protein-serine/threonine phosphatase -
JNUCC41_RS10430 2102424..2102756 + 333 WP_192207533.1 anti-sigma factor antagonist -
JNUCC41_RS10435 2102753..2103226 + 474 WP_098372177.1 anti-sigma B factor RsbW -
JNUCC41_RS10440 2103204..2103992 + 789 WP_034306363.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12955.06 Da        Isoelectric Point: 7.2029

>T173466 WP_034306610.1 NZ_CP062163:2098982-2099332 [Brevibacillus sp. JNUCC-41]
IVVKRGDVYFADLSPVVGSEQGGTRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEPMMQKVNEALQISLGLIEF

Download         Length: 351 bp

>T173466 NZ_CP080223:1879221-1879472 [Escherichia coli O141:H4]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCATAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10713.13 Da        Isoelectric Point: 5.9054

>AT173466 WP_034306380.1 NZ_CP062163:2098693-2098974 [Brevibacillus sp. JNUCC-41]
VSESSATREILIRLPQNFLTELDGYASEENVNRSEFIYRATKMYLRERKKKEFRESMKRGYIEMAAINLTIASEAFQAEF
EAGHCVERLVSGG

Download         Length: 282 bp

>AT173466 NZ_CP080223:1879469-1879723 [Escherichia coli O141:H4]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References