Detailed information of TA system TA173429

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA(toxin)
• Location: 4843318..4844915
• Replicon: chromosome
• Accession: NZ_CP062158
• Organism: Pseudomonas lundensis strain 2T.2.5.2

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: IF654_RS22580
• Protein ID: WP_194862854.1
• Coordinates: 4843590..4844915 (-)
• Length: 442 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A1D9ILT1
• Locus tag: IF654_RS22575
• Protein ID: WP_047283340.1
• Coordinates: 4843318..4843593 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF654_RS22550	4838697..4839797	+	1101	WP_194862857.1	polyamine ABC transporter substrate-binding protein	-
IF654_RS22555	4839844..4841391	-	1548	WP_194862856.1	PLP-dependent aminotransferase family protein	-
IF654_RS22560	4841481..4842110	+	630	WP_047279065.1	FMN-binding negative transcriptional regulator	-
IF654_RS22565	4842115..4842567	+	453	WP_169837059.1	GNAT family N-acetyltransferase	-
IF654_RS22570	4842582..4843262	+	681	WP_194862855.1	GNAT family N-acetyltransferase	-
IF654_RS22575	4843318..4843593	-	276	WP_047283340.1	helix-turn-helix domain-containing protein	Antitoxin
IF654_RS22580	4843590..4844915	-	1326	WP_194862854.1	HipA domain-containing protein	Toxin
IF654_RS22585	4845424..4845846	+	423	WP_141229995.1	hypothetical protein	-
IF654_RS22590	4846024..4846932	+	909	WP_094988375.1	hypothetical protein	-
IF654_RS22595	4847066..4848874	-	1809	WP_047279057.1	sodium-extruding oxaloacetate decarboxylase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-385)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-82)

Sequences

Toxin

Protein

• Length: 442 a.a.
• Molecular weight: 49614.82 Da
• Isoelectric Point: 6.3244

>T173429 WP_194862854.1 NZ_CP062158:c4844915-4843590 [Pseudomonas lundensis]
MFQLTLQLYSDGQWQDAMTLLFPEPEKGFDGPCRFGYKQDYLLQNLDLIDSPFMKSVSARVPLGWDAHNVKKTPAFLHDI
APGGAARKILIKQIGREKPEGLSIDLFLLGRSTPAPIGHLRVKESFERLDTLAPLGFARQDVIDRDNRFLEYAHEQGAAI
GGATGAGGEAPKLLMAQSAEGLLYPDATLADVDVKQHWFIKFARNRALRLDCDILRSEFMYYKALQALGIETVPAQGLAL
EEGRKPSLWMQRFDRKVTAQGVERLAVESMYSLAQVTQAGSDMTHHHVLKLLASLWTQAGQHDEIPDMVADYLRRDLLNK
ILGNSDNHGRNTAIIRDVDALRLAPIYDLAPMVMDDEGITRTTKWSREVERAGQINWRAACESLKEIIDPDSAFERLRAD
AELLRPLPDVLRAQGLPDVTMDHPHIALKHLDQRLREWGLK

Nucleotide

• Length: 1326 bp

>T173429 NZ_CP080172:c1790892-1790785 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGACGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10235.09 Da
• Isoelectric Point: 10.8992

>AT173429 WP_047283340.1 NZ_CP062158:c4843593-4843318 [Pseudomonas lundensis]
MTVSIDARRLMIEAIEADLARGEITLGDAVKRLRGEVTKLQQTQFARMCKISVRTLIQIEHNEGNPTLKSLNAVFKPFGL
QMGVVRLPRPF

Nucleotide

• Length: 276 bp

>AT173429 NZ_CP080172:1790939-1791005 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Antitoxin

• AlphaFold DB: A0A1D9ILT1