Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 4297583..4298179 Replicon chromosome
Accession NZ_CP062158
Organism Pseudomonas lundensis strain 2T.2.5.2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag IF654_RS20195 Protein ID WP_047275161.1
Coordinates 4297583..4297885 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2C8F2H1
Locus tag IF654_RS20200 Protein ID WP_047275159.1
Coordinates 4297889..4298179 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF654_RS20180 4294508..4295719 + 1212 WP_048376786.1 bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase -
IF654_RS20185 4295712..4296809 + 1098 WP_094987581.1 cobalt-precorrin-5B (C(1))-methyltransferase -
IF654_RS20190 4296806..4297534 + 729 WP_094987582.1 cobalt-precorrin-6A reductase -
IF654_RS20195 4297583..4297885 + 303 WP_047275161.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IF654_RS20200 4297889..4298179 + 291 WP_047275159.1 putative addiction module antidote protein Antitoxin
IF654_RS20205 4298287..4298685 + 399 WP_047279973.1 DUF2946 domain-containing protein -
IF654_RS20210 4298734..4299228 + 495 WP_047279972.1 copper chaperone PCu(A)C -
IF654_RS20215 4299277..4299645 + 369 WP_047273187.1 DUF2946 domain-containing protein -
IF654_RS20220 4299739..4301829 + 2091 WP_194862116.1 TonB-dependent copper receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-92)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11368.21 Da        Isoelectric Point: 9.4668

>T173428 WP_047275161.1 NZ_CP062158:4297583-4297885 [Pseudomonas lundensis]
MITLEQTHEFAKWLSSLKDKTGQARILARIRAAGLGHFADCEPVGDRVYEMRIHCGPGYRVYYARKGEVIYLLLMGGDKT
TQVRDIKRAKHIAKTLSCED

Download         Length: 303 bp

>T173428 NZ_CP080172:c1790356-1790249 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10318.67 Da        Isoelectric Point: 4.7526

>AT173428 WP_047275159.1 NZ_CP062158:4297889-4298179 [Pseudomonas lundensis]
MTEQFTRFDTADYLKTPSEMAAYLDACFEEDPGDGSLIRAALNDIARAQGMSQISRDTGLGRESLYKALGSSGNPEFATI
IKVMKALGLKLHASAA

Download         Length: 291 bp

>AT173428 NZ_CP080172:1790409-1790470 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2C8F2H1

References