Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4773..5410 Replicon plasmid pPL-38ph
Accession NZ_CP062157
Organism Pseudomonas lundensis strain 2T.2.5.2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag IF654_RS00025 Protein ID WP_095008565.1
Coordinates 4773..4955 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag IF654_RS00030 Protein ID WP_095008564.1
Coordinates 4988..5410 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF654_RS00005 277..1248 + 972 WP_143518354.1 hypothetical protein -
IF654_RS00010 2068..2724 + 657 WP_095008609.1 AAA family ATPase -
IF654_RS00015 2788..3039 + 252 WP_095008608.1 hypothetical protein -
IF654_RS00020 3162..4697 + 1536 WP_095008607.1 hypothetical protein -
IF654_RS00025 4773..4955 + 183 WP_095008565.1 type II toxin-antitoxin system HicA family toxin Toxin
IF654_RS00030 4988..5410 + 423 WP_095008564.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IF654_RS00035 5504..5692 + 189 WP_095008563.1 hypothetical protein -
IF654_RS00040 5863..6213 + 351 WP_095008562.1 hypothetical protein -
IF654_RS00045 6210..6404 + 195 WP_095008561.1 hypothetical protein -
IF654_RS00050 6454..6642 + 189 WP_095008560.1 hypothetical protein -
IF654_RS00055 6642..7055 + 414 WP_095008559.1 hypothetical protein -
IF654_RS00060 7548..8000 - 453 WP_095008557.1 hypothetical protein -
IF654_RS00065 8029..8289 - 261 WP_095008556.1 hypothetical protein -
IF654_RS00070 8369..9031 - 663 WP_095008555.1 S24 family peptidase -
IF654_RS00075 9222..9428 + 207 WP_143518348.1 hypothetical protein -
IF654_RS00080 9412..10005 + 594 WP_095008553.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..38377 38377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6864.03 Da        Isoelectric Point: 10.5498

>T173426 WP_095008565.1 NZ_CP062157:4773-4955 [Pseudomonas lundensis]
MKCSEFRRWLLAQGAEFKPAKGSHFKVYLNGKSTIFADHGSKEMHEGLRKTIIKQLGLKD

Download         Length: 183 bp

>T173426 NZ_CP080172:c1027742-1027524 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15449.87 Da        Isoelectric Point: 4.9533

>AT173426 WP_095008564.1 NZ_CP062157:4988-5410 [Pseudomonas lundensis]
MYQYPLELHTEPTGVWLSCPDIPEMNASGDTLGEAFAEALDGFESALSLYVEQRRKIPAASAARDPAMVLHLPALTVAKI
MLWNAMLDEGVSRAELARRMGCTRQVVDRLVDFLHSSKIEQVERALGLLGRRLSLVLEAA

Download         Length: 423 bp

>AT173426 NZ_CP080172:c1028142-1027768 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References