Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 811325..812901 Replicon plasmid pVP-19-VB00998
Accession NZ_CP062152
Organism Vibrio parahaemolyticus strain 19-VB00998

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag IF561_RS29145 Protein ID WP_264400186.1
Coordinates 811325..812650 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag IF561_RS29150 Protein ID WP_264400185.1
Coordinates 812644..812901 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF561_RS29100 (IF561_29055) 806633..806941 - 309 WP_258667753.1 hypothetical protein -
IF561_RS29105 (IF561_29060) 806950..807174 - 225 WP_021485441.1 hypothetical protein -
IF561_RS29110 (IF561_29065) 807374..807970 + 597 WP_053314410.1 hypothetical protein -
IF561_RS29115 (IF561_29070) 808070..808354 + 285 WP_053314411.1 hypothetical protein -
IF561_RS29120 (IF561_29075) 808409..809071 + 663 WP_053314412.1 DUF262 domain-containing protein -
IF561_RS29125 (IF561_29080) 809170..809574 + 405 WP_053317874.1 hypothetical protein -
IF561_RS29130 (IF561_29085) 809608..809871 + 264 WP_045592346.1 hypothetical protein -
IF561_RS29135 (IF561_29090) 810046..810489 + 444 WP_264400188.1 EF-hand domain-containing protein -
IF561_RS29140 (IF561_29095) 810603..811289 + 687 WP_264400187.1 hypothetical protein -
IF561_RS29145 (IF561_29100) 811325..812650 - 1326 WP_264400186.1 type II toxin-antitoxin system HipA family toxin Toxin
IF561_RS29150 (IF561_29105) 812644..812901 - 258 WP_264400185.1 helix-turn-helix domain-containing protein Antitoxin
IF561_RS29155 (IF561_29110) 813137..813982 - 846 WP_264400184.1 hypothetical protein -
IF561_RS29160 (IF561_29115) 814117..814989 + 873 WP_264400183.1 ATPase, T2SS/T4P/T4SS family -
IF561_RS29165 (IF561_29120) 814979..815431 + 453 WP_264400182.1 hypothetical protein -
IF561_RS29170 (IF561_29125) 815455..815859 - 405 WP_264400181.1 hypothetical protein -
IF561_RS29175 (IF561_29130) 815915..816922 - 1008 WP_258667745.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..882154 882154


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 49429.69 Da        Isoelectric Point: 6.7014

>T173423 WP_264400186.1 NZ_CP062152:c812650-811325 [Vibrio parahaemolyticus]
MVKQLRVLMNGESVGVFTKEPSGAHSFQYGEDWLNSSKSRPISLSIPLRREPYRGDIVINFFDNLLPDNPQVRDRIVARY
GAKTKQPFDLLEKIGRDSVGAITLIPEGEPIPEFKGIRATELSLIKLEQVLNSYADNIPLGMVDGNDDFRISIAGAQEKT
ALLKLDGRWYIPQGATPTTHIIKLPIGEIRTQDSVLDLTTSVDNELVCMRLSEAFGLPTASCDVIRAGGVRALAVERFDR
RFSQLKDWIVRLPQEDFCQVSGMPSASKYESDGGIGIEGIMDHLLGSEVPQEDRRTFMRSQVLFYLLAAIDGHSKNFSLF
IEPHGKYRLTPLYDIMSAYPLMGGRGLHERKIKLAMGLKASSGYKRKWHQIQPRHFIGTARLVKYSSDSMRDILDEFITD
CGQVIDLVGNDLPDDINENVRDKIFEGLTKSVKKLSLGLNE

Download         Length: 1326 bp

>T173423 NZ_CP080172:395634-395984 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9663.00 Da        Isoelectric Point: 7.2045

>AT173423 WP_264400185.1 NZ_CP062152:c812901-812644 [Vibrio parahaemolyticus]
MLITSSRQLAIHLRDERKSRKLSQAKVADPVGIKQDTVSKFEVNPETTSIQTLFRILSSLNLEMHIVPKGQSIEPKTDNE
SDETW

Download         Length: 258 bp

>AT173423 NZ_CP080172:395389-395640 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References