Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3208346..3208981 Replicon chromosome
Accession NZ_CP062147
Organism Komagataeibacter hansenii strain C110

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IFJ82_RS13950 Protein ID WP_192264975.1
Coordinates 3208346..3208756 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IFJ82_RS13955 Protein ID WP_192266580.1
Coordinates 3208757..3208981 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFJ82_RS13925 3203693..3203872 + 180 Protein_2722 recombinase family protein -
IFJ82_RS13930 3203963..3204232 - 270 WP_192264970.1 helix-turn-helix domain-containing protein -
IFJ82_RS13935 3204446..3206110 - 1665 WP_192264972.1 hypothetical protein -
IFJ82_RS13940 3206238..3206723 - 486 WP_192266578.1 DUF2285 domain-containing protein -
IFJ82_RS13945 3207382..3208284 + 903 WP_192264974.1 zinc ribbon domain-containing protein -
IFJ82_RS13950 3208346..3208756 - 411 WP_192264975.1 tRNA(fMet)-specific endonuclease VapC Toxin
IFJ82_RS13955 3208757..3208981 - 225 WP_192266580.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IFJ82_RS13960 3209161..3209586 + 426 WP_192264976.1 hypothetical protein -
IFJ82_RS13965 3209613..3211151 - 1539 WP_192264978.1 recombinase family protein -
IFJ82_RS13970 3211284..3212228 + 945 Protein_2731 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3195168..3233769 38601


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15580.80 Da        Isoelectric Point: 6.2382

>T173419 WP_192264975.1 NZ_CP062147:c3208756-3208346 [Komagataeibacter hansenii]
MLRYLLDTNLCIRVLRDRPQGLRPRFNNCAEELCISDVVLYELLYGAERSSDPVRTRREVEHFAARLAILPFDSEAAAHT
ADIRAELERNGRIIGPYDLMIAGHARSRGLIVVTGNLREFQRVEGLRTEDWLTDTV

Download         Length: 411 bp

>T173419 NZ_CP080166:c21161-20886 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACTTGC
GGCCGCCAGAACGGTGCAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8348.59 Da        Isoelectric Point: 6.2751

>AT173419 WP_192266580.1 NZ_CP062147:c3208981-3208757 [Komagataeibacter hansenii]
MLTRTTLFLSNRSQAVRLPKMVAFGEQVRDVVIMSEGSRRIIAPADAAWDDFFAAPRVDLGERNQPAMQEREAL

Download         Length: 225 bp

>AT173419 NZ_CP080166:c21445-21161 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTCATTACCGCGCATGTGCCATTACCAATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGAAATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References