Detailed information of TA system TA173417

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4065988..4067559
• Replicon: chromosome
• Accession: NZ_CP062146
• Organism: Proteus mirabilis strain S012

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A411AN16
• Locus tag: H6P66_RS18875
• Protein ID: WP_036895880.1
• Coordinates: 4065988..4067301 (-)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: H6P66_RS18880
• Protein ID: WP_004249771.1
• Coordinates: 4067302..4067559 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H6P66_RS18855	4061158..4061961	+	804	WP_004249775.1	energy transducer TonB	-
H6P66_RS18860	4062015..4063976	-	1962	WP_049208705.1	hypothetical protein	-
H6P66_RS18865	4064008..4064937	-	930	WP_004246518.1	metallophosphoesterase	-
H6P66_RS18870	4065122..4065586	-	465	WP_004246516.1	DUF1097 domain-containing protein	-
H6P66_RS18875	4065988..4067301	-	1314	WP_036895880.1	type II toxin-antitoxin system HipA family toxin	Toxin
H6P66_RS18880	4067302..4067559	-	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
H6P66_RS18885	4067708..4069072	-	1365	WP_004246513.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
H6P66_RS18890	4069209..4070849	-	1641	WP_004246512.1	membrane protein insertase YidC	-
H6P66_RS18895	4070852..4071112	-	261	WP_012368639.1	membrane protein insertion efficiency factor YidD	-
H6P66_RS18900	4071076..4071435	-	360	WP_004246510.1	ribonuclease P protein component	-
H6P66_RS18905	4071453..4071596	-	144	WP_004246509.1	50S ribosomal protein L34	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49698.84 Da
• Isoelectric Point: 6.5023

>T173417 WP_036895880.1 NZ_CP062146:c4067301-4065988 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDVKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T173417 NZ_CP080165:158163-158579 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT173417 WP_004249771.1 NZ_CP062146:c4067559-4067302 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT173417 NZ_CP080165:157936-158166 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: A0A411AN16

Antitoxin

• AlphaFold DB: B4F0T9