Detailed information of TA system TA173416

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 3800368..3801017
• Replicon: chromosome
• Accession: NZ_CP062146
• Organism: Proteus mirabilis strain S012

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: B4EZB9
• Locus tag: H6P66_RS17720
• Protein ID: WP_012368534.1
• Coordinates: 3800368..3800787 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: B4EZC0
• Locus tag: H6P66_RS17725
• Protein ID: WP_012368535.1
• Coordinates: 3800784..3801017 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H6P66_RS17690	3795645..3796523	-	879	WP_049203255.1	23S rRNA pseudouridine(2604) synthase RluF	-
H6P66_RS17695	3796699..3797613	-	915	WP_004249085.1	fatty acid biosynthesis protein FabY	-
H6P66_RS17700	3797637..3798074	-	438	WP_004246810.1	D-tyrosyl-tRNA(Tyr) deacylase	-
H6P66_RS17705	3798155..3798772	-	618	WP_004246809.1	glucose-1-phosphatase	-
H6P66_RS17710	3799426..3799842	-	417	WP_049208252.1	hypothetical protein	-
H6P66_RS17715	3799820..3800143	-	324	WP_049208253.1	hypothetical protein	-
H6P66_RS17720	3800368..3800787	-	420	WP_012368534.1	type II toxin-antitoxin system VapC family toxin	Toxin
H6P66_RS17725	3800784..3801017	-	234	WP_012368535.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
H6P66_RS17730	3801769..3803604	-	1836	WP_004246802.1	ribosome-dependent GTPase TypA	-
H6P66_RS17735	3803964..3805373	+	1410	WP_004246801.1	glutamate--ammonia ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (9-56)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15371.88 Da
• Isoelectric Point: 7.7288

>T173416 WP_012368534.1 NZ_CP062146:c3800787-3800368 [Proteus mirabilis]
VKKVYMLDTNICSFIMREQPISLLEKLQKCVMNHDTIVISAITYSEMRFGAIGKKASPKHNRLVDAFCERVDAILAWDKA
AVDATTVIKKCLSDVGLPIGNNDSAIAGHAVAVNAILVTNNTREFSRVEGLKIEDWTHV

Nucleotide

• Length: 420 bp

>T173416 NZ_CP080165:153300-153716 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8890.06 Da
• Isoelectric Point: 4.4870

>AT173416 WP_012368535.1 NZ_CP062146:c3801017-3800784 [Proteus mirabilis]
MRTRTVAVFKNGSNRAIRLPKDFDFDGVNELEISRDGDCIILRPVKPNWISLQNEEKADSDFLLERDDVIEEGRVIL

Nucleotide

• Length: 234 bp

>AT173416 NZ_CP080165:153073-153303 [Escherichia coli]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: B4EZB9

Antitoxin

• AlphaFold DB: B4EZC0