Detailed information of TA system TA173415

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3779796..3780495
• Replicon: chromosome
• Accession: NZ_CP062146
• Organism: Proteus mirabilis strain S012

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: H6P66_RS17615
• Protein ID: WP_004249093.1
• Coordinates: 3779796..3780182 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: H6P66_RS17620
• Protein ID: WP_004246828.1
• Coordinates: 3780175..3780495 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H6P66_RS17600	3775815..3776396	-	582	WP_004246833.1	DNA-3-methyladenine glycosylase I	-
H6P66_RS17605	3776647..3777552	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
H6P66_RS17610	3777562..3779634	+	2073	WP_004246830.1	glycine--tRNA ligase subunit beta	-
H6P66_RS17615	3779796..3780182	+	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H6P66_RS17620	3780175..3780495	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
H6P66_RS17625	3780544..3780978	-	435	WP_004246827.1	hypothetical protein	-
H6P66_RS17630	3780971..3781855	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
H6P66_RS17635	3782072..3783358	-	1287	WP_049196833.1	DUF3748 domain-containing protein	-
H6P66_RS17640	3783495..3784112	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
H6P66_RS17645	3784414..3785037	+	624	WP_004246821.1	guanylate kinase	-
H6P66_RS17650	3785092..3785367	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T173415 WP_004249093.1 NZ_CP062146:3779796-3780182 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T173415 NZ_CP080165:c148888-148583 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT173415 WP_004246828.1 NZ_CP062146:3780175-3780495 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT173415 NZ_CP080165:c149108-148890 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97