Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 3198931..3199952 | Replicon | chromosome |
| Accession | NZ_CP062146 | ||
| Organism | Proteus mirabilis strain S012 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | A0A8E4FRK4 |
| Locus tag | H6P66_RS14925 | Protein ID | WP_017827532.1 |
| Coordinates | 3199383..3199952 (+) | Length | 190 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | B4F2H3 |
| Locus tag | H6P66_RS14920 | Protein ID | WP_004245528.1 |
| Coordinates | 3198931..3199383 (+) | Length | 151 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H6P66_RS14900 | 3194718..3195248 | - | 531 | WP_004245524.1 | RNA pyrophosphohydrolase | - |
| H6P66_RS14905 | 3195516..3196529 | + | 1014 | WP_004250228.1 | thiamine ABC transporter substrate binding subunit | - |
| H6P66_RS14910 | 3196529..3198109 | + | 1581 | WP_004245526.1 | thiamine/thiamine pyrophosphate ABC transporter permease ThiP | - |
| H6P66_RS14915 | 3198102..3198803 | + | 702 | WP_049201584.1 | thiamine ABC transporter ATP-binding protein ThiQ | - |
| H6P66_RS14920 | 3198931..3199383 | + | 453 | WP_004245528.1 | helix-turn-helix domain-containing protein | Antitoxin |
| H6P66_RS14925 | 3199383..3199952 | + | 570 | WP_017827532.1 | PIN domain-containing protein | Toxin |
| H6P66_RS14930 | 3200068..3202422 | + | 2355 | WP_049207719.1 | DNA polymerase II | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 190 a.a. Molecular weight: 21601.08 Da Isoelectric Point: 7.0180
>T173413 WP_017827532.1 NZ_CP062146:3199383-3199952 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKDPP
MTVETFLGCLQKQKLPQFISHLRAFQILL
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKDPP
MTVETFLGCLQKQKLPQFISHLRAFQILL
Download Length: 570 bp
>T173413 NZ_CP080165:c90484-90335 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 151 a.a. Molecular weight: 16700.15 Da Isoelectric Point: 5.7723
>AT173413 WP_004245528.1 NZ_CP062146:3198931-3199383 [Proteus mirabilis]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY
Download Length: 453 bp
>AT173413 NZ_CP080165:90528-90589 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|