Detailed information of TA system TA173412

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1541570..1542215
• Replicon: chromosome
• Accession: NZ_CP062146
• Organism: Proteus mirabilis strain S012

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: B4ET86
• Locus tag: H6P66_RS07185
• Protein ID: WP_004247035.1
• Coordinates: 1542030..1542215 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B4ET85
• Locus tag: H6P66_RS07180
• Protein ID: WP_004247034.1
• Coordinates: 1541570..1541983 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H6P66_RS07150	1537115..1537273	-	159	WP_004247025.1	hypothetical protein	-
H6P66_RS07155	1537725..1537901	+	177	WP_185966348.1	hypothetical protein	-
H6P66_RS07160	1538078..1538824	-	747	WP_004247794.1	class I SAM-dependent methyltransferase	-
H6P66_RS07165	1539675..1540253	+	579	WP_004247796.1	alpha/beta hydrolase	-
H6P66_RS07170	1540366..1540659	-	294	Protein_1378	LysE family transporter	-
H6P66_RS07175	1540833..1541474	-	642	WP_065424673.1	response regulator	-
H6P66_RS07180	1541570..1541983	-	414	WP_004247034.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H6P66_RS07185	1542030..1542215	-	186	WP_004247035.1	type II toxin-antitoxin system HicA family toxin	Toxin
H6P66_RS07190	1542326..1543096	+	771	Protein_1382	DUF1073 domain-containing protein	-
H6P66_RS07195	1543390..1543542	+	153	WP_155289810.1	hypothetical protein	-
H6P66_RS07200	1543655..1544206	-	552	WP_049208654.1	PH domain-containing protein	-
H6P66_RS07205	1544310..1544585	-	276	WP_049208653.1	hypothetical protein	-
H6P66_RS07215	1545003..1546736	-	1734	WP_012367752.1	LPS biosynthesis-modulating metalloenzyme YejM	-
H6P66_RS07220	1546760..1546987	-	228	WP_004247042.1	YejL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1541570..1554209	12639

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7049.30 Da
• Isoelectric Point: 10.9659

>T173412 WP_004247035.1 NZ_CP062146:c1542215-1542030 [Proteus mirabilis]
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN

Nucleotide

• Length: 186 bp

>T173412 NZ_CP080163:4941118-4941375 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15251.98 Da
• Isoelectric Point: 4.3830

>AT173412 WP_004247034.1 NZ_CP062146:c1541983-1541570 [Proteus mirabilis]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Nucleotide

• Length: 414 bp

>AT173412 NZ_CP080163:4941387-4941932 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: B4ET86

Antitoxin

• AlphaFold DB: B4ET85