Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 759444..760104 Replicon chromosome
Accession NZ_CP062146
Organism Proteus mirabilis strain S012

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H6P66_RS03535 Protein ID WP_004245133.1
Coordinates 759444..759869 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8E3RLN2
Locus tag H6P66_RS03540 Protein ID WP_004245128.1
Coordinates 759862..760104 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H6P66_RS03505 754741..755190 + 450 WP_004245139.1 transcriptional regulator NrdR -
H6P66_RS03510 755239..756396 + 1158 WP_004245138.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
H6P66_RS03515 756609..757079 + 471 WP_004245137.1 6,7-dimethyl-8-ribityllumazine synthase -
H6P66_RS03520 757108..757521 + 414 WP_004245136.1 transcription antitermination factor NusB -
H6P66_RS03525 757615..758595 + 981 WP_004245135.1 thiamine-phosphate kinase -
H6P66_RS03530 758681..759016 - 336 WP_004245134.1 phnA family protein -
H6P66_RS03535 759444..759869 - 426 WP_004245133.1 type II toxin-antitoxin system VapC family toxin Toxin
H6P66_RS03540 759862..760104 - 243 WP_004245128.1 hypothetical protein Antitoxin
H6P66_RS03545 760220..761227 - 1008 WP_012367471.1 ribose operon transcriptional repressor RbsR -
H6P66_RS03550 761232..762158 - 927 WP_004245126.1 ribokinase -
H6P66_RS03555 762236..763126 - 891 WP_004245125.1 ribose ABC transporter substrate-binding protein RbsB -
H6P66_RS03560 763166..764131 - 966 WP_004245124.1 ribose ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15924.18 Da        Isoelectric Point: 6.4879

>T173411 WP_004245133.1 NZ_CP062146:c759869-759444 [Proteus mirabilis]
MIKYLLDTNIVIFTIKRKPEFLLPKFNQHAEQLAISTITLAELIFGAEKSVNPAKNLATVNDFVSRLTVLSYDDLAAFHY
GDIRATLEKQGKRIGDNDLHIAAHARSKGLIVVTNNTREFERVDGLRIEDWTVINSDPQTD

Download         Length: 426 bp

>T173411 NZ_CP080163:4823978-4824130 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9390.48 Da        Isoelectric Point: 4.6182

>AT173411 WP_004245128.1 NZ_CP062146:c760104-759862 [Proteus mirabilis]
MIQYGKVFMSNRTQNVRLPAETRFPDDVKEVFVRVKGKERIITPIQNAWDSFFLSEKSVTDDFLSERPDQATSERESFDD

Download         Length: 243 bp

>AT173411 NZ_CP080163:c4823929-4823872 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References