Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 100029..101627 Replicon chromosome
Accession NZ_CP062146
Organism Proteus mirabilis strain S012

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag H6P66_RS00490 Protein ID WP_049208475.1
Coordinates 100029..101372 (-) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag H6P66_RS00495 Protein ID WP_041701484.1
Coordinates 101376..101627 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H6P66_RS00470 95646..96830 + 1185 WP_004246423.1 multidrug efflux MFS transporter EmrD -
H6P66_RS00475 96940..98472 - 1533 WP_004246422.1 glycerol kinase GlpK -
H6P66_RS00480 98515..99330 - 816 WP_004246421.1 aquaporin -
H6P66_RS00485 99627..99869 + 243 WP_012368679.1 cell division protein ZapB -
H6P66_RS00490 100029..101372 - 1344 WP_049208475.1 type II toxin-antitoxin system HipA family toxin Toxin
H6P66_RS00495 101376..101627 - 252 WP_041701484.1 helix-turn-helix domain-containing protein Antitoxin
H6P66_RS00500 102217..102735 - 519 WP_004246419.1 ribonuclease E activity regulator RraA -
H6P66_RS00505 102844..103761 - 918 WP_020946557.1 1,4-dihydroxy-2-naphthoate polyprenyltransferase -
H6P66_RS00510 103860..105200 - 1341 WP_049208477.1 HslU--HslV peptidase ATPase subunit -
H6P66_RS00515 105213..105743 - 531 WP_004246416.1 ATP-dependent protease subunit HslV -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-399)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-63)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 49811.26 Da        Isoelectric Point: 5.3203

>T173410 WP_049208475.1 NZ_CP062146:c101372-100029 [Proteus mirabilis]
MKAQILSVAMNGDLVGKLTKNTDGGMSFQYAEEWLAEPGARAISLSLPLQKGRIIGSAVYNFFSNLLPDSEAIIDRMQIR
FKVKTNHPFDLLAAVGRDCVGAIQLYSPDTEIPSVMETHAEPLNENQIEELLDGYQTAPLGMSEDVDFRISLAGAQEKTA
LLWYQDCWQRPQGSTPTSHIFKLPIGLIEHHNIDLRESCENEWLCLCIAREFGFPVTNAELAIFGQKKVLIVERFDRKWS
SSGNWLLRLPQEDCCQALSVAPALKYESDGGPGIESIMTLLLGSQKAIDDREMFFKSQILFWMLAAIDGHGKNFSIFIES
GTSFRLTPLYDVMSAFPIFEARGIEIKKAKMAMALQGKNRQYNFSMIQPRHFISTATKVGFPTKTAMELMIDMAEKTDAV
IATVSSQLPADFPEHISNAIFSGLSIQADKIKRWSSGTSPQNMMVSN

Download         Length: 1344 bp

>T173410 NZ_CP080163:4336795-4337013 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9390.83 Da        Isoelectric Point: 9.8955

>AT173410 WP_041701484.1 NZ_CP062146:c101627-101376 [Proteus mirabilis]
MKITTPSMLAAAIHDLRKQSKLTQAQTAEQVGLRQATVSEFENNPESTKLETLFKILASLELELHVVKRGKNLSEGKVWN
KEW

Download         Length: 252 bp

>AT173410 NZ_CP080163:4336395-4336769 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References