Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4644302..4644818 Replicon chromosome
Accession NZ_CP062138
Organism Klebsiella quasipneumoniae strain 203 19001

Toxin (Protein)


Gene name relE Uniprot ID A0A2A5MHL2
Locus tag IG177_RS22480 Protein ID WP_050533673.1
Coordinates 4644302..4644586 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag IG177_RS22485 Protein ID WP_002886901.1
Coordinates 4644576..4644818 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG177_RS22465 4639462..4641117 + 1656 WP_050533675.1 alpha,alpha-phosphotrehalase -
IG177_RS22470 4641503..4643641 + 2139 WP_004206513.1 anaerobic ribonucleoside-triphosphate reductase -
IG177_RS22475 4643834..4644298 + 465 WP_050533674.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IG177_RS22480 4644302..4644586 - 285 WP_050533673.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IG177_RS22485 4644576..4644818 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IG177_RS22490 4644896..4646806 - 1911 WP_050533672.1 BglG family transcription antiterminator -
IG177_RS22495 4646829..4647980 - 1152 WP_050533671.1 lactonase family protein -
IG177_RS22500 4648047..4648787 - 741 WP_004206507.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11093.90 Da        Isoelectric Point: 10.3341

>T173406 WP_050533673.1 NZ_CP062138:c4644586-4644302 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQKLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCDKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T173406 NZ_CP080163:3459861-3459968 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT173406 WP_002886901.1 NZ_CP062138:c4644818-4644576 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT173406 NZ_CP080163:c3459808-3459747 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MHL2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References