Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3959976..3960595 Replicon chromosome
Accession NZ_CP062138
Organism Klebsiella quasipneumoniae strain 203 19001

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag IG177_RS19255 Protein ID WP_002892050.1
Coordinates 3960377..3960595 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag IG177_RS19250 Protein ID WP_002892066.1
Coordinates 3959976..3960350 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG177_RS19240 3955130..3956323 + 1194 WP_023288645.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IG177_RS19245 3956346..3959492 + 3147 WP_023288644.1 multidrug efflux RND transporter permease subunit -
IG177_RS19250 3959976..3960350 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
IG177_RS19255 3960377..3960595 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
IG177_RS19260 3960754..3961320 + 567 WP_050533075.1 maltose O-acetyltransferase -
IG177_RS19265 3961292..3961423 - 132 WP_032428629.1 hypothetical protein -
IG177_RS19270 3961457..3961927 + 471 WP_023288642.1 YlaC family protein -
IG177_RS19275 3961896..3963353 - 1458 WP_050533076.1 PLP-dependent aminotransferase family protein -
IG177_RS19280 3963454..3964152 + 699 WP_044521289.1 GNAT family N-acetyltransferase -
IG177_RS19285 3964149..3964289 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
IG177_RS19290 3964289..3964552 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T173405 WP_002892050.1 NZ_CP062138:3960377-3960595 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T173405 NZ_CP080163:c3283470-3283294 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTGGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCAAGGGCGACGCAGTGTCATGCCGCGTCACCCCAGTGATGAGATAAAAGAACCATTGCGTAAAGCAATCCTGAAGC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT173405 WP_002892066.1 NZ_CP062138:3959976-3960350 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT173405 NZ_CP080163:c3283248-3282832 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ATGAGCTAATCCCGTTGCCTTCGCCATTAACTAACAACGATCACTTTATTGAAGTGCCTTTAAGTATCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References