Detailed information of TA system TA173404

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2562473..2564061
• Replicon: chromosome
• Accession: NZ_CP062138
• Organism: Klebsiella quasipneumoniae strain 203 19001

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A7L8QI06
• Locus tag: IG177_RS12565
• Protein ID: WP_050534228.1
• Coordinates: 2562473..2563795 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A2N4W0X3
• Locus tag: IG177_RS12570
• Protein ID: WP_023289667.1
• Coordinates: 2563795..2564061 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IG177_RS12545	2559408..2559656	+	249	WP_004205912.1	hypothetical protein	-
IG177_RS12550	2559948..2560166	+	219	WP_002904808.1	ParD-like family protein	-
IG177_RS12555	2560147..2560929	+	783	WP_023289670.1	type I methionyl aminopeptidase	-
IG177_RS12560	2561164..2562456	+	1293	WP_044523014.1	glycoside hydrolase family 10 protein	-
IG177_RS12565	2562473..2563795	-	1323	WP_050534228.1	type II toxin-antitoxin system HipA family toxin	Toxin
IG177_RS12570	2563795..2564061	-	267	WP_023289667.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
IG177_RS12575	2564437..2564763	-	327	WP_044523006.1	hydroxyisourate hydrolase	-
IG177_RS12580	2564760..2565260	-	501	WP_050534227.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
IG177_RS12585	2565238..2566617	-	1380	WP_050534226.1	purine permease	-
IG177_RS12590	2566963..2568117	+	1155	WP_050534225.1	FAD-dependent urate hydroxylase HpxO	-
IG177_RS12595	2568098..2569021	-	924	WP_023289662.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49111.42 Da
• Isoelectric Point: 8.9176

>T173404 WP_050534228.1 NZ_CP062138:c2563795-2562473 [Klebsiella quasipneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDDEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDGAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATRGRKTEINAIYPRHFLATAKAVNFPRDQMLAILDEFADRVP
QAIESARRTLPADFSAHVWRAITENMLKLHARLQQGLQAR

Nucleotide

• Length: 1323 bp

>T173404 NZ_CP080163:3233989-3234267 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCATCGACTTGCTGTGATTGATGCGGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9891.25 Da
• Isoelectric Point: 7.3163

>AT173404 WP_023289667.1 NZ_CP062138:c2564061-2563795 [Klebsiella quasipneumoniae]
MHSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETATAP
DNTTDLDW

Nucleotide

• Length: 267 bp

>AT173404 NZ_CP080163:3234267-3234551 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGTCTGGCAGAGGCTGAA
AAAACGGTGGATGTGTCGCGATTACGCCGTCTGGTTACGCAATAA

Structures

Toxin

• AlphaFold DB: A0A7L8QI06

Antitoxin

• AlphaFold DB: A0A2N4W0X3