Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4816593..4817236 Replicon chromosome
Accession NZ_CP062122
Organism Pseudomonas sp. ADPe

Toxin (Protein)


Gene name vapC Uniprot ID A0A1A5DDI8
Locus tag IG194_RS21915 Protein ID WP_058488742.1
Coordinates 4816593..4817006 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID W5IS21
Locus tag IG194_RS21920 Protein ID WP_009620639.1
Coordinates 4817006..4817236 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG194_RS21895 4812043..4813365 - 1323 WP_058488739.1 aminotransferase class III-fold pyridoxal phosphate-dependent enzyme -
IG194_RS21900 4813362..4814426 - 1065 WP_058488740.1 phosphotransferase -
IG194_RS21905 4814579..4815313 + 735 WP_009620642.1 SDR family oxidoreductase -
IG194_RS21910 4815378..4816067 + 690 WP_058488741.1 GntR family transcriptional regulator -
IG194_RS21915 4816593..4817006 - 414 WP_058488742.1 tRNA(fMet)-specific endonuclease VapC Toxin
IG194_RS21920 4817006..4817236 - 231 WP_009620639.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IG194_RS21925 4817421..4818122 - 702 WP_009620638.1 ATP-binding cassette domain-containing protein -
IG194_RS21930 4818126..4818893 - 768 WP_009620637.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
IG194_RS21935 4818890..4820143 - 1254 WP_058488743.1 high-affinity branched-chain amino acid ABC transporter permease LivM -
IG194_RS21940 4820140..4821060 - 921 WP_009620635.1 high-affinity branched-chain amino acid ABC transporter permease LivH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15253.55 Da        Isoelectric Point: 6.6415

>T173392 WP_058488742.1 NZ_CP062122:c4817006-4816593 [Pseudomonas sp. ADPe]
MLKFMLDTNICIFTIKNKPQVVREAFNQHHGQLAISSVTLMELIYGAEKSSMPEHNLGIVEGFAARLEVLDYDGNAAAHT
GQLRAELARIGKPIDPYDQMIAGHARSRGLILVSNNLREFERVPGLRLEDWTVAPSP

Download         Length: 414 bp

>T173392 NZ_CP080163:18986-19396 [Escherichia coli]
ATGAAATTATTACCCGACACACATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGTCTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACAGGCCTGATGACACGTAA
TAACTACAGAATGGTAAATAACATTACCCTGGGTAGCATCCGGGGGCGAAACGATGAAACTTTCCCTGACGCTGGAAGCC
GACAGCATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.43 Da        Isoelectric Point: 4.3094

>AT173392 WP_009620639.1 NZ_CP062122:c4817236-4817006 [Pseudomonas sp. ADPe]
MEQGAVFQSNRSQAVRLPKAVALPEDVKRVDVVAIGRTRILTPAGESWDSWFDGENVSADFMSEREQPAEQEREGF

Download         Length: 231 bp

>AT173392 NZ_CP080163:18527-18895 [Escherichia coli]
GTGTCAGACACACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGCATCAGAGGCCGGT
TCAGCGATGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A5DDI8

Antitoxin

Source ID Structure
AlphaFold DB A0A1A5DDH0

References