Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 4373586..4374175 Replicon chromosome
Accession NZ_CP062122
Organism Pseudomonas sp. ADPe

Toxin (Protein)


Gene name hicA Uniprot ID A0A1A5D7X7
Locus tag IG194_RS19920 Protein ID WP_058488551.1
Coordinates 4373586..4373837 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1A5D829
Locus tag IG194_RS19925 Protein ID WP_043318088.1
Coordinates 4373834..4374175 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG194_RS19900 4369475..4371178 - 1704 WP_058489715.1 type IV-A pilus assembly ATPase PilB -
IG194_RS19905 4371411..4371887 + 477 WP_082996272.1 pilin -
IG194_RS19915 4372267..4373340 + 1074 WP_058488549.1 diguanylate cyclase -
IG194_RS19920 4373586..4373837 + 252 WP_058488551.1 type II toxin-antitoxin system HicA family toxin Toxin
IG194_RS19925 4373834..4374175 + 342 WP_043318088.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IG194_RS19930 4374241..4374468 + 228 WP_043272290.1 DUF433 domain-containing protein -
IG194_RS19935 4374656..4375852 - 1197 WP_058488552.1 type II toxin-antitoxin system HipA family toxin -
IG194_RS19940 4375852..4376103 - 252 WP_009617650.1 helix-turn-helix domain-containing protein -
IG194_RS19945 4376402..4377250 - 849 WP_058488553.1 carboxylating nicotinate-nucleotide diphosphorylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9565.03 Da        Isoelectric Point: 10.0940

>T173390 WP_058488551.1 NZ_CP062122:4373586-4373837 [Pseudomonas sp. ADPe]
MSRNEKLLAKLLNESTSFTWQELVTLLRWLGYRQLEGSGSRVKFDNGDPQALINLHKPHPGNELKAYVRRQIIEHLKAGE
LIP

Download         Length: 252 bp

>T173390 NZ_CP080158:c21161-20886 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACTTGC
GGCCGCCAGAACGGTGCAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12586.02 Da        Isoelectric Point: 5.0823

>AT173390 WP_043318088.1 NZ_CP062122:4373834-4374175 [Pseudomonas sp. ADPe]
VNNLLQYRGYYGSIEASTEDNCLFGKLLFIRALVNYEGETVAELQAAFREAVDDYLATCQAQGQEPEVPCKGSFNVRVGH
DLHLAASLAANRQHMSLNDLTRQALSEYLQHHG

Download         Length: 342 bp

>AT173390 NZ_CP080158:c21445-21161 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTCATTACCGCGCATGTGCCATTACCAATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGAAATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A5D7X7

Antitoxin

Source ID Structure
AlphaFold DB A0A1A5D829

References