Detailed information of TA system TA173389

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 4365758..4366227
• Replicon: chromosome
• Accession: NZ_CP062122
• Organism: Pseudomonas sp. ADPe

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IG194_RS19870
• Protein ID: WP_024128153.1
• Coordinates: 4365758..4366033 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W5IQM6
• Locus tag: IG194_RS19875
• Protein ID: WP_009617620.1
• Coordinates: 4366033..4366227 (-)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IG194_RS19835	4361470..4362768	-	1299	WP_058488540.1	NAD(P)/FAD-dependent oxidoreductase	-
IG194_RS19840	4362815..4362988	-	174	WP_009617611.1	DUF3094 domain-containing protein	-
IG194_RS19845	4363058..4363687	-	630	WP_058488541.1	DUF1780 domain-containing protein	-
IG194_RS19850	4363820..4364236	+	417	WP_058488542.1	GNAT family N-acetyltransferase	-
IG194_RS19855	4364239..4364715	+	477	WP_058488543.1	hypothetical protein	-
IG194_RS19860	4364712..4365428	+	717	WP_058488544.1	energy-coupling factor ABC transporter permease	-
IG194_RS19865	4365536..4365751	+	216	WP_058488545.1	hypothetical protein	-
IG194_RS19870	4365758..4366033	-	276	WP_024128153.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
IG194_RS19875	4366033..4366227	-	195	WP_009617620.1	hypothetical protein	Antitoxin
IG194_RS19880	4366493..4366702	-	210	WP_043272268.1	DNA gyrase inhibitor YacG	-
IG194_RS19885	4366699..4367307	-	609	WP_058488546.1	dephospho-CoA kinase	-
IG194_RS19890	4367381..4368253	-	873	WP_058488547.1	A24 family peptidase	-
IG194_RS19895	4368254..4369471	-	1218	WP_058488548.1	type II secretion system F family protein	-
IG194_RS19900	4369475..4371178	-	1704	WP_058489715.1	type IV-A pilus assembly ATPase PilB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10478.03 Da
• Isoelectric Point: 7.3551

>T173389 WP_024128153.1 NZ_CP062122:c4366033-4365758 [Pseudomonas sp. ADPe]
VLSIIWRRSASDDLATILAYIANEDPQAARRLKERVESAVLPLAQHPYLYRHGRVPGTREVVIHPNYILVYRIDAECIEV
VSVLHSRQEYP

Nucleotide

• Length: 276 bp

>T173389 NZ_CP080158:2068-2355 [Escherichia coli]
ATGACTTATACGGTTAAATTCAGGGATGATGCACTGAAAGAATGGCTCAGACTGGATAAGGCCATTCAGCAGCAGTTCGC
AAAAAAACTAAAAAAATGCAGTGAAAATCCTCATATAGCCTCTGCAAAACTACGTGGATTAAAAGATTGCTACAAAATAA
AACTTCGCGCATCAGGTTTTCGTCTGGTCTATCAGGTGATTGATGACATGTTAATTATTGCGGTTGTCGCAGTAGGTAAA
CGTGAACGTAGTCATGTTTACAATCTCGCCAGCGAGAGAATGAGATAG

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7293.07 Da
• Isoelectric Point: 4.9890

>AT173389 WP_009617620.1 NZ_CP062122:c4366227-4366033 [Pseudomonas sp. ADPe]
MSARLSPIVSEFETPEQAASHDRWFRQKVQKSLTDNQPGRPHDEVMVDMDAIIAQAEARRQGND

Nucleotide

• Length: 195 bp

>AT173389 NZ_CP080158:1820-2071 [Escherichia coli]
ATGCCCAGTATAATTTTGTCTGACACCAGTGCAAGCGTCAGTGAACTGAAAAAAAATCCAATGGCGACAGTCAGTGCCGG
AGAGGGTTATCCTGTTGCCATTCTTAACCGGAATCAGCCTGCATTCTACTGTGTTCCAGCTGAGCTCTATGAAAGGATGC
TTGATGCCCTGGATGACCAGGAGCTGGTGAAACTGGTTACTGAGCGCAGCAGTCAGCCTCTGCATTATGTGGACCTGGAC
AGTTATTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A1A5D6N4