Detailed information of TA system TA173388

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3817264..3817898
• Replicon: chromosome
• Accession: NZ_CP062122
• Organism: Pseudomonas sp. ADPe

Toxin (Protein)

• Gene name: VapC1
• Uniprot ID: A0A1A5D7M4
• Locus tag: IG194_RS17220
• Protein ID: WP_058488323.1
• Coordinates: 3817264..3817674 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: -
• Locus tag: IG194_RS17225
• Protein ID: WP_134163499.1
• Coordinates: 3817671..3817898 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IG194_RS17200	3813393..3813926	+	534	WP_009613171.1	(2Fe-2S)-binding protein	-
IG194_RS17205	3813929..3815164	+	1236	WP_058488320.1	cytochrome c	-
IG194_RS17210	3815166..3816134	+	969	WP_058488321.1	XdhC family protein	-
IG194_RS17215	3816131..3816736	+	606	WP_058488322.1	nucleotidyltransferase family protein	-
IG194_RS17220	3817264..3817674	-	411	WP_058488323.1	type II toxin-antitoxin system VapC family toxin	Toxin
IG194_RS17225	3817671..3817898	-	228	WP_134163499.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
IG194_RS17230	3818014..3819138	-	1125	WP_058489705.1	class I SAM-dependent methyltransferase	-
IG194_RS17235	3819267..3820043	+	777	WP_058488324.1	ferredoxin--NADP reductase	-
IG194_RS17240	3820232..3821785	+	1554	WP_058488325.1	TerC family protein	-
IG194_RS17245	3821803..3822216	-	414	WP_043268871.1	large-conductance mechanosensitive channel protein MscL	-
IG194_RS17250	3822407..3822649	+	243	WP_009613144.1	YdcH family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-127)

Antitoxin

• SpoVT-AbrB domain (2-38)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15533.89 Da
• Isoelectric Point: 7.7739

>T173388 WP_058488323.1 NZ_CP062122:c3817674-3817264 [Pseudomonas sp. ADPe]
VKYLLDTNILIYLLKNRPESVARRVNALPADAGLCMSFFTYAELLKGAERSTRRSEVLRQLERLTRQVTVVYDGTPRLCE
HYATQFTRLKLAGTPIGANDLWIACHALALEATLVTHNTREFERIDGLRLEDWAVE

Nucleotide

• Length: 411 bp

>T173388 NZ_CP080157:158191-158607 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8586.49 Da
• Isoelectric Point: 4.1169

>AT173388 WP_134163499.1 NZ_CP062122:c3817898-3817671 [Pseudomonas sp. ADPe]
MNGNSQAVRIPQEFRLDASRVEIRRQANGDLVIHPLPEDRGEALLQALSGFDDEFIEALEEGQREQPPMQEREEL

Nucleotide

• Length: 228 bp

>AT173388 NZ_CP080157:157964-158194 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: A0A1A5D7M4